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Molecules 2014, 19(5), 5674-5691; doi:10.3390/molecules19055674

Synthesis and Antifungal Activity of Benzamidine Derivatives Carrying 1,2,3-Triazole Moieties

, , ,  and *
Research & Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Yangling 712100, China
* Author to whom correspondence should be addressed.
Received: 18 March 2014 / Revised: 20 April 2014 / Accepted: 25 April 2014 / Published: 2 May 2014
(This article belongs to the Section Organic Synthesis)
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Eighteen novel benzamidine derivatives containing 1,2,3-triazole moieties were synthesized. The in vitro and in vivo fungicidal acitivities of the title compounds and the arylamidine intermediates against Colletotrichum lagenarium and Botrytis cinerea were tested. The synthesized benzamidines exhibited weak antifungal activities in vitro against the tested fungi, but some of the compounds showed excellent activities in vivo to the same strains. Among the compounds tested, 9b showed 79% efficacy in vivo against C. lagenarium at a concentration of 200 μg/mL, and the efficacy of compound 16d (90%) toward the same strain was even superior than that of the commercial fungicide carbendazim (85%).
Keywords: amidine; 1,2,3-triazole; antifungal activity; synthesis amidine; 1,2,3-triazole; antifungal activity; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, G.; Zhou, Y.; Cai, C.; Lu, J.; Zhang, X. Synthesis and Antifungal Activity of Benzamidine Derivatives Carrying 1,2,3-Triazole Moieties. Molecules 2014, 19, 5674-5691.

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