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Molecules 2014, 19(4), 4595-4607; doi:10.3390/molecules19044595

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

1 Laboratory for Research in Experimental Neurochemistry, Campus Ministro Petrônio Portella, Federal University of Piauí, Teresina, PI 64049550, Brazil 2 Laboratory of Bioassays for Drug Research, Federal University of Pernambuco, Recife, PE 50670-901, Brazil 3 Department of Chemistry, Federal Rural University of Pernambuco, Recife, PE 52171900, Brazil 4 Laboratory of Pharmaceutical Technology Federal University of Paraíba, João Pessoa, PB 58051-900, Brazil 5 Laboratory Chemistry of Bioactive Natural and Synthetic Products, Federal University of Piauí, Teresina, PI 64049550, Brazil 6 Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Mededibag, Chittagong-4000, Bangladesh
* Author to whom correspondence should be addressed.
Received: 16 October 2013 / Revised: 17 January 2014 / Accepted: 23 January 2014 / Published: 11 April 2014
(This article belongs to the Section Medicinal Chemistry)
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This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.
Keywords: antioxidant activity; cytotoxicity; riparins antioxidant activity; cytotoxicity; riparins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nunes, G.B.L.; Policarpo, P.R.; Costa, L.M.; da Silva, T.G.; Militão, G.C.G.; Câmara, C.A.; Barbosa Filho, J.M.; Gutierrez, S.J.C.; Islam, M.T.; de Freitas, R.M. In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds. Molecules 2014, 19, 4595-4607.

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