In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds
AbstractThis study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.
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Nunes, G.B.L.; Policarpo, P.R.; Costa, L.M.; da Silva, T.G.; Militão, G.C.G.; Câmara, C.A.; Barbosa Filho, J.M.; Gutierrez, S.J.C.; Islam, M.T.; de Freitas, R.M. In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds. Molecules 2014, 19, 4595-4607.
Nunes GBL, Policarpo PR, Costa LM, da Silva TG, Militão GCG, Câmara CA, Barbosa Filho JM, Gutierrez SJC, Islam MT, de Freitas RM. In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds. Molecules. 2014; 19(4):4595-4607.Chicago/Turabian Style
Nunes, Geandra B.L.; Policarpo, Paola R.; Costa, Luciana M.; da Silva, Teresinha G.; Militão, Gardenia C.G.; Câmara, Celso A.; Barbosa Filho, José M.; Gutierrez, Stanley J.C.; Islam, Mohammed T.; de Freitas, Rivelilson M. 2014. "In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds." Molecules 19, no. 4: 4595-4607.