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Molecules 2014, 19(4), 4595-4607; doi:10.3390/molecules19044595
Article

In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds

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Received: 16 October 2013 / Revised: 17 January 2014 / Accepted: 23 January 2014 / Published: 11 April 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.
Keywords: antioxidant activity; cytotoxicity; riparins antioxidant activity; cytotoxicity; riparins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nunes, G.B.L.; Policarpo, P.R.; Costa, L.M.; da Silva, T.G.; Militão, G.C.G.; Câmara, C.A.; Barbosa Filho, J.M.; Gutierrez, S.J.C.; Islam, M.T.; de Freitas, R.M. In Vitro Antioxidant and Cytotoxic Activity of Some Synthetic Riparin-Derived Compounds. Molecules 2014, 19, 4595-4607.

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