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Molecules 2014, 19(4), 4608-4623; doi:10.3390/molecules19044608
Article

Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis

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Received: 3 March 2014; in revised form: 9 April 2014 / Accepted: 9 April 2014 / Published: 14 April 2014
(This article belongs to the Section Metabolites)
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Abstract: Three new ursane- and four new oleanane- type triterpenoids 17 were isolated, along with six known compounds 813, from the methanolic extract of Microtropis fokienensis. All structures were elucidated by mass and NMR spectroscopic methods. The isolates 410 and known compounds 1417 that were previously isolated from this material were evaluated for anti-inflammatory activity based on effects against superoxide anion generation and elastase release by neutrophils in response to fMLP/CB. 11α,30-Dihydroxy-2,3-seco-olean-12-en-2,3-dioic anhydride (7) was the first triterpene anhydride from the genus of Microtropis to have the ring A expanded to a seven-membered ring; it showed significant anti-inflammatory activity against superoxide anion generation and elastase release. Unexpectedly, 30-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (17) showed the best effect against superoxide anion generation and elastase release with IC50 values of 0.06 ± 0.01 and 1.03 ± 0.35 µg/mL, respectively. Compound 17 had a dioic acid function, and compound 7 had an anhydride function modification in ring A; both showed promising activity in the target assays.
Keywords: Microtropis fokienensis; triterpenoids; ursane; oleanane; anti-inflammatory Microtropis fokienensis; triterpenoids; ursane; oleanane; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, I.-H.; Du, Y.-C.; Hwang, T.-L.; Chen, I.-F.; Lan, Y.-H.; Yen, H.-F.; Chang, F.-R.; Wu, Y.-C. Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis. Molecules 2014, 19, 4608-4623.

AMA Style

Chen I-H, Du Y-C, Hwang T-L, Chen I-F, Lan Y-H, Yen H-F, Chang F-R, Wu Y-C. Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis. Molecules. 2014; 19(4):4608-4623.

Chicago/Turabian Style

Chen, I-Hsiao; Du, Ying-Chi; Hwang, Tsong-Long; Chen, I-Fen; Lan, Yu-Hsuan; Yen, Hsin-Fu; Chang, Fang-Rong; Wu, Yang-Chang. 2014. "Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis." Molecules 19, no. 4: 4608-4623.


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