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Molecules 2014, 19(4), 4548-4559; doi:10.3390/molecules19044548

Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 7 March 2014 / Revised: 4 April 2014 / Accepted: 8 April 2014 / Published: 11 April 2014
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Four new withanolides named dmetelins A–D (compounds 14), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.
Keywords: Datura metel L.; withanolides; dmetelins; NO inhibition Datura metel L.; withanolides; dmetelins; NO inhibition

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yang, B.-Y.; Guo, R.; Li, T.; Liu, Y.; Wang, C.-F.; Shu, Z.-P.; Wang, Z.-B.; Zhang, J.; Xia, Y.-G.; Jiang, H.; Wang, Q.-H.; Kuang, H.-X. Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production. Molecules 2014, 19, 4548-4559.

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