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Molecules 2014, 19(4), 4548-4559; doi:10.3390/molecules19044548
Article

Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

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Received: 7 March 2014 / Revised: 4 April 2014 / Accepted: 8 April 2014 / Published: 11 April 2014
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Abstract

Four new withanolides named dmetelins A–D (compounds 14), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.
Keywords: Datura metel L.; withanolides; dmetelins; NO inhibition Datura metel L.; withanolides; dmetelins; NO inhibition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, B.-Y.; Guo, R.; Li, T.; Liu, Y.; Wang, C.-F.; Shu, Z.-P.; Wang, Z.-B.; Zhang, J.; Xia, Y.-G.; Jiang, H.; Wang, Q.-H.; Kuang, H.-X. Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production. Molecules 2014, 19, 4548-4559.

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