Next Article in Journal
Synthetic Applications of Intramolecular Thiol-Ene “Click” Reactions
Previous Article in Journal
Aroma-Active Compounds in Jinhua Ham Produced With Different Fermentation Periods
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(11), 19114-19136; doi:10.3390/molecules191119114

Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity

1
Department of Pharmaceutical Sciences II, Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa-Iasi, Universitatii Str. 16, 700115 Iasi, Romania
2
Section of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway
3
Department of Traditional Medicine, University of Bamako, PB 1746 Bamako, Mali
4
Department of Pharmaceutical Sciences I, Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa-Iasi, Universitatii Str. 16, 700115 Iasi, Romania
5
Department of Biological Sciences, University of Cyprus, Kallipoleos 75, 1678 Nicosia, Cyprus
6
Department Medical I, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa-Iasi, Universitatii Str. 16, 700115 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Received: 10 August 2014 / Revised: 12 November 2014 / Accepted: 12 November 2014 / Published: 19 November 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [345 KB, uploaded 19 November 2014]   |  

Abstract

The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, the aim of this study was to screen the root extracts for their in vitro antioxidant activity and phenolic content. The roots were extracted successively with chloroform, ethyl acetate, ethanol and water. The antioxidant activity of root extracts was evaluated in both cell-free and cell-based assays. Their chemical characterization was performed by Fourier transform infrared spectroscopy (FT-IR) whereas the total phenolic content was determined by the Folin-Ciocalteu method. The ethyl acetate extract displayed the highest phenolic content and was found to be the most active in the free radical scavenging and lipid peroxidation inhibition assays; it also showed a high antioxidant activity in MCF-12F cells. This study suggests a potential use of the ethyl acetate extract of Vernonia kotschyana not only as an antioxidant agent in gastroduodenal ulcers and gastritis, but also in other disorders characterized by high levels of oxidative stress. View Full-Text
Keywords: Vernonia kotschyana; ethyl acetate extract; free radical scavenging activity; lipid peroxidation inhibition; FT-IR spectroscopy; phenolic content Vernonia kotschyana; ethyl acetate extract; free radical scavenging activity; lipid peroxidation inhibition; FT-IR spectroscopy; phenolic content
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vasincu, A.; Paulsen, B.S.; Diallo, D.; Vasincu, I.; Aprotosoaie, A.C.; Bild, V.; Charalambous, C.; Constantinou, A.I.; Miron, A.; Gavrilescu, C.M. Vernonia kotschyana Roots: Therapeutic Potential via Antioxidant Activity. Molecules 2014, 19, 19114-19136.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top