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Molecules 2014, 19(11), 18590-18603; doi:10.3390/molecules191118590

Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging

1
Department of Biochemistry, State University of Maringá, 87020900 Maringá, Brazil
2
Department of Morphological Sciences, State University of Maringá, 87020900 Maringá, Brazil
*
Author to whom correspondence should be addressed.
Received: 7 October 2014 / Revised: 6 November 2014 / Accepted: 7 November 2014 / Published: 13 November 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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Abstract

An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract. The A. blazei treatment tended to maintain the ROS contents of the brain and liver at lower levels, but a significant difference was found only at the age of 23 months and in the brain. The TBARS levels in the brain were maintained at lower levels by the A. blazei treatment during the whole aging process with a specially pronounced difference at the age of 12 months. The total antioxidant capacity in the brain was higher in treated rats only at the age of 12 months. Compared with previous studies in which old rats (21 months) were treated during a short period of 21 days with 200 mg/kg, the effects of the A. blazei extract in the present study tended to be less pronounced. The results also indicate that the long and constant treatment presented a tendency of becoming less effective at ages above 12 months. View Full-Text
Keywords: aging; oxidative stress; oxidative damage; brain; liver; A. blazei treatment aging; oxidative stress; oxidative damage; brain; liver; A. blazei treatment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Sá-Nakanishi, A.B.; Soares, A.A.; Natali, M.R.M.; Comar, J.F.; Peralta, R.M.; Bracht, A. Effects of the Continuous Administration of an Agaricus blazei Extract to Rats on Oxidative Parameters of the Brain and Liver during Aging. Molecules 2014, 19, 18590-18603.

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