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Molecules 2014, 19(11), 18268-18282; doi:10.3390/molecules191118268

Efficacy Evaluation of a Multifunctional Cosmetic Formulation: The Benefits of a Combination of Active Antioxidant Substances

Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Av do Cafe s/n, Monte Alegre, Ribeirao Preto, SP 14040-903, Brazil
Author to whom correspondence should be addressed.
Received: 29 April 2014 / Revised: 30 September 2014 / Accepted: 30 September 2014 / Published: 10 November 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
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This study presents the association of active antioxidants substances in a multifunctional cosmetic formulation with established efficacy against signs of aging. A multifunctional cosmetic formulation containing an association of UV filters and antioxidant substances (liposoluble vitamins A, C and E, Ginkgo biloba and Phorphyra umbilicalis extracts) was evaluated. This formulation was submitted to a clinical efficacy study using biophysics techniques and skin images analysis (digital photography imaging systems, 20 MHz ultrasound, and reflectance confocal microscopy). The volunteers applied the formulation containing the UV filters and antioxidant substances during the day and the formulation with antioxidant substances and without the UV filters at night, for 90 days. The formulation increased the hydration and protected the skin barrier function after a single application. At the long term assessment the formulation provided an improvement in skin barrier function and skin hydration to the deeper layers of the epidermis, leading to an improvement in skin appearance by reducing wrinkles and skin roughness. The multifunctional cosmetic formulation studied can be suggested to preventing signs of aging and improving skin conditions. In addition, this study presents the benefits of associating different active antioxidants substances in a single cosmetic formulation to prevent skin aging. View Full-Text
Keywords: multifunctional cosmetics; image analysis; clinical efficacy; skin aging; antioxidants multifunctional cosmetics; image analysis; clinical efficacy; skin aging; antioxidants

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gianeti, M.D.; Maia Campos, P.M.B.G. Efficacy Evaluation of a Multifunctional Cosmetic Formulation: The Benefits of a Combination of Active Antioxidant Substances. Molecules 2014, 19, 18268-18282.

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