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Molecules 2014, 19(11), 17078-17106; doi:10.3390/molecules191117078

Endocannabinoids, Related Compounds and Their Metabolic Routes

1
Department of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, Italy
2
European Center for Brain Research/IRCCS Santa Lucia Foundation, 00143 Rome, Italy
3
Department of Movement, Human and Health Sciences, Foro Italico University of Rome, 00128 Rome, Italy
4
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy
5
Center of Integrated Research, Campus Bio-Medico University of Rome, 00135 Rome, Italy
*
Authors to whom correspondence should be addressed.
Received: 1 August 2014 / Revised: 16 October 2014 / Accepted: 16 October 2014 / Published: 24 October 2014
(This article belongs to the Section Metabolites)
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Abstract

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed. View Full-Text
Keywords: anandamide; 2-arachidonoylglycerol; endocannabinoid metabolic routes; fatty acids anandamide; 2-arachidonoylglycerol; endocannabinoid metabolic routes; fatty acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fezza, F.; Bari, M.; Florio, R.; Talamonti, E.; Feole, M.; Maccarrone, M. Endocannabinoids, Related Compounds and Their Metabolic Routes. Molecules 2014, 19, 17078-17106.

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