Next Article in Journal
Phytotoxicity of 4,8-Dihydroxy-1-tetralone Isolated from Carya cathayensis Sarg. to Various Plant Species
Previous Article in Journal
Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Molecules 2014, 19(10), 15440-15451; doi:10.3390/molecules191015440

A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats

1
Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt
2
Department of Chemistry and Biochemistry, Faculty of Science, Tabuk University, Tabuk P.O. Box 699, Tabuk 71491, Saudi Arabia
3
Faculty of Specific Education, Zagazig University, Zagazig 44519, Egypt
4
Department of Basic and Clinical Medical Science, Faculty of Dentistry, P. Qaseem University, Qaseem 51411, Saudi Arabia
5
Department of Home Economics, Faculty of Specific Education, Kafr ElSheikh University, Kafr ElSheikh 33516, Egypt
*
Author to whom correspondence should be addressed.
Received: 2 July 2014 / Revised: 30 July 2014 / Accepted: 26 August 2014 / Published: 26 September 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [886 KB, uploaded 26 September 2014]   |  

Abstract

A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group. View Full-Text
Keywords: Lepidium sativum; isoflavonoid; hepatotoxicity Lepidium sativum; isoflavonoid; hepatotoxicity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sakran, M.; Selim, Y.; Zidan, N. A New Isoflavonoid from Seeds of Lepidium sativum L. and Its Protective Effect on Hepatotoxicity Induced by Paracetamol in Male Rats. Molecules 2014, 19, 15440-15451.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top