Molecules 2013, 18(9), 10367-10377; doi:10.3390/molecules180910367
Communication

3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

1,2email, 3email, 4email, 5email and 1,* email
Received: 8 June 2013; in revised form: 12 August 2013 / Accepted: 15 August 2013 / Published: 27 August 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.
Keywords: anthraquinone; BHAQ; cytotoxic; MDA-MB231; MCF-7; migration
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MDPI and ACS Style

Abu, N.; Akhtar, M.N.; Ho, W.Y.; Yeap, S.K.; Alitheen, N.B. 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231. Molecules 2013, 18, 10367-10377.

AMA Style

Abu N, Akhtar MN, Ho WY, Yeap SK, Alitheen NB. 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231. Molecules. 2013; 18(9):10367-10377.

Chicago/Turabian Style

Abu, Nadiah; Akhtar, M. N.; Ho, Wan Y.; Yeap, Swee K.; Alitheen, Noorjahan B. 2013. "3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231." Molecules 18, no. 9: 10367-10377.


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