Next Article in Journal
3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
Previous Article in Journal
Palladium-Catalyzed Synthesis of Natural and Unnatural 2-, 5-, and 7-Oxygenated Carbazole Alkaloids from N-Arylcyclohexane Enaminones
Molecules 2013, 18(9), 10352-10366; doi:10.3390/molecules180910352
Article

Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen

1
,
2
,
2, 2
,
2
,
2
,
1,2
 and
1,2,*
1 Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China 2 Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China
* Author to whom correspondence should be addressed.
Received: 22 July 2013 / Revised: 12 August 2013 / Accepted: 20 August 2013 / Published: 26 August 2013
(This article belongs to the Section Metabolites)
Download PDF [353 KB, uploaded 18 June 2014]

Abstract

Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
Keywords: Panax notoginseng; root; protopanaxatriol type saponins; L6 cell; mitochondrial oxidative stress Panax notoginseng; root; protopanaxatriol type saponins; L6 cell; mitochondrial oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Zhang, Y.; Han, L.-F.; Sakah, K.J.; Wu, Z.-Z.; Liu, L.-L.; Agyemang, K.; Gao, X.-M.; Wang, T. Bioactive Protopanaxatriol Type Saponins Isolated from the Roots of Panax Notoginseng (Burk.) F. H. Chen. Molecules 2013, 18, 10352-10366.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert