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Molecules 2013, 18(9), 10378-10396; doi:10.3390/molecules180910378

Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

1,2,* , 1,* , 3, 4, 1, 5, 5 and 3
1 Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan 2 Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Pakistan 3 Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan 4 Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan 5 Chimie, Université de Montréal, Montréal, QC H3C3J7, Canada
* Authors to whom correspondence should be addressed.
Received: 14 July 2013 / Revised: 23 July 2013 / Accepted: 26 July 2013 / Published: 27 August 2013
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A series of N-pivaloyl-N-(alkyl/aryl)-N′′-pyridylguanidine of general formula C4H9CONHC(NR1R2)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
Keywords: guanidine; antitumor; antioxidant; antimicrobial assay guanidine; antitumor; antioxidant; antimicrobial assay
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Said, M.; Badshah, A.; Shah, N.A.; Khan, H.; Murtaza, G.; Vabre, B.; Zargarian, D.; Khan, M.R. Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines. Molecules 2013, 18, 10378-10396.

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