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Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Pakistan
Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan
Chimie, Université de Montréal, Montréal, QC H3C3J7, Canada
* Authors to whom correspondence should be addressed.
Received: 14 July 2013; in revised form: 23 July 2013 / Accepted: 26 July 2013 / Published: 27 August 2013
Abstract: A series of N-pivaloyl-N′-(alkyl/aryl)-N′′-pyridylguanidine of general formula C4H9CONHC(NR1R2)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
Keywords: guanidine; antitumor; antioxidant; antimicrobial assay
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Said, M.; Badshah, A.; Shah, N.A.; Khan, H.; Murtaza, G.; Vabre, B.; Zargarian, D.; Khan, M.R. Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines. Molecules 2013, 18, 10378-10396.
Said M, Badshah A, Shah NA, Khan H, Murtaza G, Vabre B, Zargarian D, Khan MR. Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines. Molecules. 2013; 18(9):10378-10396.
Said, Muhammad; Badshah, Amin; Shah, Naseer A.; Khan, Hizbullah; Murtaza, Ghulam; Vabre, Boris; Zargarian, Davit; Khan, Muhammad R. 2013. "Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines." Molecules 18, no. 9: 10378-10396.