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Molecules 2013, 18(9), 10378-10396; doi:10.3390/molecules180910378
Article

Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines

1,2,* , 1,* , 3, 4, 1, 5, 5 and 3
Received: 14 July 2013; in revised form: 23 July 2013 / Accepted: 26 July 2013 / Published: 27 August 2013
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Abstract: A series of N-pivaloyl-N-(alkyl/aryl)-N′′-pyridylguanidine of general formula C4H9CONHC(NR1R2)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
Keywords: guanidine; antitumor; antioxidant; antimicrobial assay guanidine; antitumor; antioxidant; antimicrobial assay
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Said, M.; Badshah, A.; Shah, N.A.; Khan, H.; Murtaza, G.; Vabre, B.; Zargarian, D.; Khan, M.R. Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines. Molecules 2013, 18, 10378-10396.

AMA Style

Said M, Badshah A, Shah NA, Khan H, Murtaza G, Vabre B, Zargarian D, Khan MR. Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines. Molecules. 2013; 18(9):10378-10396.

Chicago/Turabian Style

Said, Muhammad; Badshah, Amin; Shah, Naseer A.; Khan, Hizbullah; Murtaza, Ghulam; Vabre, Boris; Zargarian, Davit; Khan, Muhammad R. 2013. "Antitumor, Antioxidant and Antimicrobial Studies of Substituted Pyridylguanidines." Molecules 18, no. 9: 10378-10396.


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