Molecules 2013, 18(8), 9253-9277; doi:10.3390/molecules18089253
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Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins

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Received: 6 June 2013; in revised form: 27 July 2013 / Accepted: 29 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue NMR of Proteins and Small Biomolecules)
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Abstract: Bleomycins are a family of glycopeptide antibiotics that have the ability to bind and degrade DNA when bound to key metal ions, which is believed to be responsible for their antitumor activity. Knowledge of the structures of metallo-bleomycins is vital to further characterize their mechanism of action. To this end, numerous structural studies on metallo-bleomycins have been conducted. NMR spectroscopy has had a key role in most of these studies, and has led to very important findings involving the coordination chemistry of metallo-bleomycins, and the details of many metallo-bleomycin-DNA spatial correlations for this important drug. This paper reviews the most important contributions of NMR to the bleomycin field.
Keywords: antibiotic; cancer; bleomycin; solution structures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lehmann, T.; Topchiy, E. Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins. Molecules 2013, 18, 9253-9277.

AMA Style

Lehmann T, Topchiy E. Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins. Molecules. 2013; 18(8):9253-9277.

Chicago/Turabian Style

Lehmann, Teresa; Topchiy, Elena. 2013. "Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins." Molecules 18, no. 8: 9253-9277.


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