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Anti-Obesity Effect of Artemisia capillaris Extracts in High-Fat Diet-Induced Obese Rats
Functionality Evaluation Research Group, Korea Food Research Institute, Seongnam 463-746, Korea
These authors contributed equally in this work.
* Author to whom correspondence should be addressed.
Received: 20 May 2013; in revised form: 10 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
Abstract: This study evaluated the anti-obesity effects of Artemisia capillaris extracts in high-fat diet (HFD)-induced obese rats. After six weeks feeding with HFD, Wistar male rats (12-weeks-old) were divided into three groups: HFD-control group and HFD mixed with 0.4% and 0.8% Artemisia capillaris extracts treated groups. After seven weeks of treatments, the body weight gain of the 0.4% and 0.8% A. capillaris extracts treated groups were significantly less than that of the HFD-control group by 11.8% and 15.4%, respectively. Also, A. capillaris extracts treated groups showed significantly lower serum TG, TC and LDL-c levels in a dose-related manner, while causing the reverse effect in serum HDL-c, and exhibited a hepatoprotective effects in vivo, indicated by reduced hepatic lipid contents, and serum ALT and AST levels. These results show that A. capillaris extracts may prevent body weight increases and improve dyslipidemia in HFD-induced obese rats by enhancing their lipid metabolism.
Keywords: Artemisia capillaris; scoparone; hypolipidemic; anti-obesity
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MDPI and ACS Style
Lim, D.W.; Kim, Y.T.; Jang, Y.-J.; Kim, Y.-E.; Han, D. Anti-Obesity Effect of Artemisia capillaris Extracts in High-Fat Diet-Induced Obese Rats. Molecules 2013, 18, 9241-9252.
Lim DW, Kim YT, Jang Y-J, Kim Y-E, Han D. Anti-Obesity Effect of Artemisia capillaris Extracts in High-Fat Diet-Induced Obese Rats. Molecules. 2013; 18(8):9241-9252.
Lim, Dong W.; Kim, Yun T.; Jang, Yu-Jung; Kim, Young-Eon; Han, Daeseok. 2013. "Anti-Obesity Effect of Artemisia capillaris Extracts in High-Fat Diet-Induced Obese Rats." Molecules 18, no. 8: 9241-9252.