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Molecules 2013, 18(7), 8147-8159; doi:10.3390/molecules18078147
Article

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

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Received: 3 June 2013; in revised form: 1 July 2013 / Accepted: 2 July 2013 / Published: 10 July 2013
(This article belongs to the Section Organic Synthesis)
Download PDF [242 KB, uploaded 18 June 2014]
Abstract: In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
Keywords: heterocyclization; hydrazine; hydroxylamine; tricyclic isoxazoles; tricyclic pyrazoles heterocyclization; hydrazine; hydroxylamine; tricyclic isoxazoles; tricyclic pyrazoles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pinna, G.; Loriga, G.; Pinna, G.A.; Chelucci, G. Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent. Molecules 2013, 18, 8147-8159.

AMA Style

Pinna G, Loriga G, Pinna GA, Chelucci G. Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent. Molecules. 2013; 18(7):8147-8159.

Chicago/Turabian Style

Pinna, Giansalvo; Loriga, Giovanni; Pinna, Gérard A.; Chelucci, Giorgio. 2013. "Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent." Molecules 18, no. 7: 8147-8159.


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