Molecules 2013, 18(7), 8147-8159; doi:10.3390/molecules18078147
Article

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

1 Dipartimento di Chimica e Farmacia, Università di Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy 2 Istituto di Farmacologia Traslazionale, UOS Cagliari, Edificio 5, Loc Piscinamanna, 09010 Pula (CA), Italy 3 Dipartimento di Agraria, Università di Sassari, Viale Italia 39, 07100 Sassari, Italy
* Author to whom correspondence should be addressed.
Received: 3 June 2013; in revised form: 1 July 2013 / Accepted: 2 July 2013 / Published: 10 July 2013
(This article belongs to the Section Organic Synthesis)
PDF Full-text Download PDF Full-Text [242 KB, uploaded 10 July 2013 14:41 CEST]
Abstract: In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
Keywords: heterocyclization; hydrazine; hydroxylamine; tricyclic isoxazoles; tricyclic pyrazoles

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Pinna, G.; Loriga, G.; Pinna, G.A.; Chelucci, G. Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent. Molecules 2013, 18, 8147-8159.

AMA Style

Pinna G, Loriga G, Pinna GA, Chelucci G. Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent. Molecules. 2013; 18(7):8147-8159.

Chicago/Turabian Style

Pinna, Giansalvo; Loriga, Giovanni; Pinna, Gérard A.; Chelucci, Giorgio. 2013. "Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent." Molecules 18, no. 7: 8147-8159.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert