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Molecules 2013, 18(7), 8147-8159; doi:10.3390/molecules18078147
Article

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

1,* , 2
,
1
 and
3
1 Dipartimento di Chimica e Farmacia, Università di Sassari, Via F. Muroni 23/A, 07100 Sassari, Italy 2 Istituto di Farmacologia Traslazionale, UOS Cagliari, Edificio 5, Loc Piscinamanna, 09010 Pula (CA), Italy 3 Dipartimento di Agraria, Università di Sassari, Viale Italia 39, 07100 Sassari, Italy
* Author to whom correspondence should be addressed.
Received: 3 June 2013 / Revised: 1 July 2013 / Accepted: 2 July 2013 / Published: 10 July 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
Keywords: heterocyclization; hydrazine; hydroxylamine; tricyclic isoxazoles; tricyclic pyrazoles heterocyclization; hydrazine; hydroxylamine; tricyclic isoxazoles; tricyclic pyrazoles
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pinna, G.; Loriga, G.; Pinna, G.A.; Chelucci, G. Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent. Molecules 2013, 18, 8147-8159.

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