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Molecules 2013, 18(7), 8160-8167; doi:10.3390/molecules18078160
Article

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

1,†
, 2,3,†
, 1,4,5
, 1
, 1,3,4
, 2,3,4
, 1,4,5,*  and 1,2,3,4,6,7,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 4 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 6 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 27 May 2013 / Revised: 4 July 2013 / Accepted: 8 July 2013 / Published: 10 July 2013
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Abstract

A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
Keywords: flexibilisquinone; cultured soft coral; Sinularia flexibilis; anti-inflammatory; iNOS; COX-2 flexibilisquinone; cultured soft coral; Sinularia flexibilis; anti-inflammatory; iNOS; COX-2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lin, Y.-F.; Kuo, C.-Y.; Wen, Z.-H.; Lin, Y.-Y.; Wang, W.-H.; Su, J.-H.; Sheu, J.-H.; Sung, P.-J. Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis. Molecules 2013, 18, 8160-8167.

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