Molecules 2013, 18(7), 8160-8167; doi:10.3390/molecules18078160
Article

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

1,†email, 2,3,†email, 1,4,5email, 1email, 1,3,4email, 2,3,4email, 1,4,5,* email and 1,2,3,4,6,7,* email
Received: 27 May 2013; in revised form: 4 July 2013 / Accepted: 8 July 2013 / Published: 10 July 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.
Keywords: flexibilisquinone; cultured soft coral; Sinularia flexibilis; anti-inflammatory; iNOS; COX-2
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MDPI and ACS Style

Lin, Y.-F.; Kuo, C.-Y.; Wen, Z.-H.; Lin, Y.-Y.; Wang, W.-H.; Su, J.-H.; Sheu, J.-H.; Sung, P.-J. Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis. Molecules 2013, 18, 8160-8167.

AMA Style

Lin Y-F, Kuo C-Y, Wen Z-H, Lin Y-Y, Wang W-H, Su J-H, Sheu J-H, Sung P-J. Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis. Molecules. 2013; 18(7):8160-8167.

Chicago/Turabian Style

Lin, Yu-Fang; Kuo, Chao-Ying; Wen, Zhi-Hong; Lin, Yen-You; Wang, Wei-Hsien; Su, Jui-Hsin; Sheu, Jyh-Horng; Sung, Ping-Jyun. 2013. "Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis." Molecules 18, no. 7: 8160-8167.

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