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Molecules 2013, 18(7), 8136-8146; doi:10.3390/molecules18078136
Article

Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1

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1 Centro de Investigación Biomédica del Sur (CIBIS), Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico 2 Doctorado en Desarrollo de Productos Bióticos, Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, P. O. Box 24, Yautepec 62730, Morelos, Mexico
* Author to whom correspondence should be addressed.
Received: 22 April 2013 / Revised: 29 May 2013 / Accepted: 6 June 2013 / Published: 10 July 2013
(This article belongs to the Section Natural Products)
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Abstract

Species of the agave genus, such as Agave tequilana, Agave angustifolia and Agave americana are used in Mexican traditional medicine to treat inflammation-associated conditions. These plants’ leaves contain saponin compounds which show anti-inflammatory properties in different models. The goal of this investigation was to evaluate the anti-inflammatory capacity of these plants, identify which is the most active, and isolate the active compound by a bio-directed fractionation using the ear edema induced in mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) technique. A dose of 6 mg/ear of acetone extract from the three agave species induced anti-inflammatory effects, however, the one from A. americana proved to be the most active. Different fractions of this species showed biological activity. Finally the F5 fraction at 2.0 mg/ear induced an inhibition of 85.6%. We identified one compound in this fraction as (25R)-5α-spirostan-3β,6α,23α-triol-3,6-di-O-β-D-glucopyranoside (cantalasaponin-1) through 1H- and 13C-NMR spectral analysis and two dimensional experiments like DEPT NMR, COSY, HSQC and HMBC. This steroidal glycoside showed a dose dependent effect of up to 90% of ear edema inhibition at the highest dose of 1.5 mg/ear.
Keywords: Agavaceae; A. angustifolia Haw; A. tequilana Weber; A. americana; cantalasaponin-1; inflammation Agavaceae; A. angustifolia Haw; A. tequilana Weber; A. americana; cantalasaponin-1; inflammation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Monterrosas-Brisson, N.; Ocampo, M.L.A.; Jiménez-Ferrer, E.; Jiménez-Aparicio, A.R.; Zamilpa, A.; Gonzalez-Cortazar, M.; Tortoriello, J.; Herrera-Ruiz, M. Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1. Molecules 2013, 18, 8136-8146.

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