Molecules 2013, 18(7), 8136-8146; doi:10.3390/molecules18078136

Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1

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Received: 22 April 2013; in revised form: 29 May 2013 / Accepted: 6 June 2013 / Published: 10 July 2013
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Species of the agave genus, such as Agave tequilana, Agave angustifolia and Agave americana are used in Mexican traditional medicine to treat inflammation-associated conditions. These plants’ leaves contain saponin compounds which show anti-inflammatory properties in different models. The goal of this investigation was to evaluate the anti-inflammatory capacity of these plants, identify which is the most active, and isolate the active compound by a bio-directed fractionation using the ear edema induced in mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) technique. A dose of 6 mg/ear of acetone extract from the three agave species induced anti-inflammatory effects, however, the one from A. americana proved to be the most active. Different fractions of this species showed biological activity. Finally the F5 fraction at 2.0 mg/ear induced an inhibition of 85.6%. We identified one compound in this fraction as (25R)-5α-spirostan-3β,6α,23α-triol-3,6-di-O-β-D-glucopyranoside (cantalasaponin-1) through 1H- and 13C-NMR spectral analysis and two dimensional experiments like DEPT NMR, COSY, HSQC and HMBC. This steroidal glycoside showed a dose dependent effect of up to 90% of ear edema inhibition at the highest dose of 1.5 mg/ear.
Keywords: Agavaceae; A. angustifolia Haw; A. tequilana Weber; A. americana; cantalasaponin-1; inflammation
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MDPI and ACS Style

Monterrosas-Brisson, N.; Ocampo, M.L.A.; Jiménez-Ferrer, E.; Jiménez-Aparicio, A.R.; Zamilpa, A.; Gonzalez-Cortazar, M.; Tortoriello, J.; Herrera-Ruiz, M. Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1. Molecules 2013, 18, 8136-8146.

AMA Style

Monterrosas-Brisson N, Ocampo MLA, Jiménez-Ferrer E, Jiménez-Aparicio AR, Zamilpa A, Gonzalez-Cortazar M, Tortoriello J, Herrera-Ruiz M. Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1. Molecules. 2013; 18(7):8136-8146.

Chicago/Turabian Style

Monterrosas-Brisson, Nayeli; Ocampo, Martha L.A.; Jiménez-Ferrer, Enrique; Jiménez-Aparicio, Antonio R.; Zamilpa, Alejandro; Gonzalez-Cortazar, Manases; Tortoriello, Jaime; Herrera-Ruiz, Maribel. 2013. "Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1." Molecules 18, no. 7: 8136-8146.

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