Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental
3.1. General
3.2. Chemistry
3.2.1. General Procedure for the Synthesis of Ester C-5′-Substituted Derivatives 1–3
3.2.2. Procedure for the Synthesis of Ether C-5′-Substituted Derivative 4
3.3. Biological Evaluation
3.3.1. Bovine Milk β-1,4-Galactosyltransferase I Assay
3.3.2. Antifungal Assays
3.4. In Silico Target Identification
4. Conclusion
Supplementary Materials
Acknowledgments
Conflicts of Interest
References
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Paszkowska, J.; Kral, K.; Bieg, T.; Nawrot, U.; Szeja, W.; Wandzik, I. Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors. Molecules 2013, 18, 8018-8027. https://doi.org/10.3390/molecules18078018
Paszkowska J, Kral K, Bieg T, Nawrot U, Szeja W, Wandzik I. Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors. Molecules. 2013; 18(7):8018-8027. https://doi.org/10.3390/molecules18078018
Chicago/Turabian StylePaszkowska, Jadwiga, Katarzyna Kral, Tadeusz Bieg, Urszula Nawrot, Wiesław Szeja, and Ilona Wandzik. 2013. "Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors" Molecules 18, no. 7: 8018-8027. https://doi.org/10.3390/molecules18078018