Molecules 2013, 18(7), 8009-8017; doi:10.3390/molecules18078009
Article

Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae)

1email, 1email, 2email and 1,* email
Received: 29 May 2013; in revised form: 30 June 2013 / Accepted: 2 July 2013 / Published: 8 July 2013
(This article belongs to the Section Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A dichloromethane extract of the stem bark of Cryptocarya nigra showed strong in vitro inhibition of Plasmodium falciparum growth, with an IC50 value of 2.82 μg/mL. The phytochemical study of this extract has led to the isolation and characterization of four known alkaloids: (+)-N-methylisococlaurine (1), atherosperminine (2), 2-hydroxyathersperminine (3), and noratherosperminine (4). Structural elucidation of all alkaloids was accomplished by means of high field 1D- and 2D-NMR, IR, UV and LCMS spectral data. The isolated extract constituents (+)-N-methylisococlaurine (1), atherosperminine (2) and 2-hydroxy-atherosperminine (3) showed strong antiplasmodial activity, with IC50 values of 5.40, 5.80 and 0.75 μM, respectively. In addition, (+)-N-methylisocolaurine (1) and atherosperminine (2) showed high antioxidant activity in a DPPH assay with IC50 values of 29.56 ug/mL and 54.53 ug/mL respectively. Compounds 1 and 2 also both showed high antioxidant activity in the FRAP assay, with percentages of 78.54 and 70.66 respectively and in the metal chelating assay, with IC50 values of 50.08 ug/mL and 42.87 ug/mL, respectively.
Keywords: Plasmodium falciparum; Cryptocarya nigra; Lauraceae; antioxidant; antiplasmodial; activity
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MDPI and ACS Style

Nasrullah, A.A.; Zahari, A.; Mohamad, J.; Awang, K. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae). Molecules 2013, 18, 8009-8017.

AMA Style

Nasrullah AA, Zahari A, Mohamad J, Awang K. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae). Molecules. 2013; 18(7):8009-8017.

Chicago/Turabian Style

Nasrullah, Ayu A.; Zahari, Azeana; Mohamad, Jamaludin; Awang, Khalijah. 2013. "Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae)." Molecules 18, no. 7: 8009-8017.

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