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Molecules 2013, 18(7), 8018-8027; doi:10.3390/molecules18078018
Article

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

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Received: 2 May 2013; Accepted: 26 June 2013 / Published: 8 July 2013
(This article belongs to the Section Organic Synthesis)
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Abstract: New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 14 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.
Keywords: uridine; glycosyltransferase inhibitors; antifungal activity uridine; glycosyltransferase inhibitors; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Paszkowska, J.; Kral, K.; Bieg, T.; Nawrot, U.; Szeja, W.; Wandzik, I. Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors. Molecules 2013, 18, 8018-8027.

AMA Style

Paszkowska J, Kral K, Bieg T, Nawrot U, Szeja W, Wandzik I. Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors. Molecules. 2013; 18(7):8018-8027.

Chicago/Turabian Style

Paszkowska, Jadwiga; Kral, Katarzyna; Bieg, Tadeusz; Nawrot, Urszula; Szeja, Wiesław; Wandzik, Ilona. 2013. "Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors." Molecules 18, no. 7: 8018-8027.



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