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Molecules 2013, 18(7), 8018-8027; doi:10.3390/molecules18078018
Article

Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

1
,
1
,
1
,
2
,
1
 and
1,*
1 Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100 Gliwice, Poland 2 Department of Microbiology, Wroclaw Medical University, T. Chałubińskiego 4, 50-368 Wrocław, Poland
* Author to whom correspondence should be addressed.
Received: 2 May 2013 / Accepted: 26 June 2013 / Published: 8 July 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 14 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.
Keywords: uridine; glycosyltransferase inhibitors; antifungal activity uridine; glycosyltransferase inhibitors; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Paszkowska, J.; Kral, K.; Bieg, T.; Nawrot, U.; Szeja, W.; Wandzik, I. Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors. Molecules 2013, 18, 8018-8027.

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