Next Article in Journal
Solution NMR Studies on the Orientation of Membrane-Bound Peptides and Proteins by Paramagnetic Probes
Next Article in Special Issue
Synthesis and Quantitative Structure-Property Relationships of Side Chain-Modified Hyodeoxycholic Acid Derivatives
Previous Article in Journal
Ethanol Extract of Atractylodes macrocephala Protects Bone Loss by Inhibiting Osteoclast Differentiation
Previous Article in Special Issue
In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release
Article Menu

Export Article

Open AccessReview
Molecules 2013, 18(7), 7389-7406; doi:10.3390/molecules18077389

Modulation of Xenobiotic Receptors by Steroids

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
*
Author to whom correspondence should be addressed.
Received: 24 May 2013 / Revised: 13 June 2013 / Accepted: 19 June 2013 / Published: 24 June 2013
(This article belongs to the Special Issue Steroids)
View Full-Text   |   Download PDF [1081 KB, uploaded 18 June 2014]   |  

Abstract

Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of their target genes. NRs play important roles in many human diseases, including metabolic diseases and cancer, and are therefore a key class of therapeutic targets. Steroids play important roles in regulating nuclear receptors; in addition to being ligands of steroid receptors, steroids (and their metabolites) also regulate other NRs, such as the pregnane X receptor and constitutive androstane receptor (termed xenobiotic receptors), which participate in steroid metabolism. Xenobiotic receptors have promiscuous ligand-binding properties, and their structurally diverse ligands include steroids and their metabolites. Therefore, steroids, their metabolism and metabolites, xenobiotic receptors, steroid receptors, and the respective signaling pathways they regulate have functional interactions. This review discusses these functional interactions and their implications for activities mediated by steroid receptors and xenobiotic receptors, focusing on steroids that modulate pathways involving the pregnane X receptor and constitutive androstane receptor. The emphasis of the review is on structure-function studies of xenobiotic receptors bound to steroid ligands.
Keywords: nuclear receptors; pregnane X receptor: constitutive androstane receptor; steroid nuclear receptors; pregnane X receptor: constitutive androstane receptor; steroid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Banerjee, M.; Robbins, D.; Chen, T. Modulation of Xenobiotic Receptors by Steroids. Molecules 2013, 18, 7389-7406.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top