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Molecules 2013, 18(4), 3745-3759; doi:10.3390/molecules18043745
Article

In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release

*  and
Received: 25 February 2013; in revised form: 19 March 2013 / Accepted: 21 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Steroids)
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Abstract: In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthesis or directly in situ during the gel forming process. The gels prepared by both methods were studied and it was found that they had very similar macro- and microscopic properties. Furthermore, the possibility to use the gels as carriers for aromatic drugs such as 5-chloro-8-hydroxyquinoline, pyrazinecarboxamide, and antipyrine was investigated and the prepared two-component gels were studied with regard to their potential applications in drug delivery, particularly in a pH-controlled drug release.
Keywords: organogel; acid-responsive; cholesterol; in situ gelation; drug release organogel; acid-responsive; cholesterol; in situ gelation; drug release
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bunzen, H.; Kolehmainen, E. In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release. Molecules 2013, 18, 3745-3759.

AMA Style

Bunzen H, Kolehmainen E. In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release. Molecules. 2013; 18(4):3745-3759.

Chicago/Turabian Style

Bunzen, Hana; Kolehmainen, Erkki. 2013. "In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release." Molecules 18, no. 4: 3745-3759.


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