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In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release
Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014, Finland
* Author to whom correspondence should be addressed.
Received: 25 February 2013; in revised form: 19 March 2013 / Accepted: 21 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Steroids
Abstract: In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthesis or directly in situ during the gel forming process. The gels prepared by both methods were studied and it was found that they had very similar macro- and microscopic properties. Furthermore, the possibility to use the gels as carriers for aromatic drugs such as 5-chloro-8-hydroxyquinoline, pyrazinecarboxamide, and antipyrine was investigated and the prepared two-component gels were studied with regard to their potential applications in drug delivery, particularly in a pH-controlled drug release.
Keywords: organogel; acid-responsive; cholesterol; in situ gelation; drug release
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Cite This Article
MDPI and ACS Style
Bunzen, H.; Kolehmainen, E. In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release. Molecules 2013, 18, 3745-3759.
Bunzen H, Kolehmainen E. In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release. Molecules. 2013; 18(4):3745-3759.
Bunzen, Hana; Kolehmainen, Erkki. 2013. "In Situ Formation of Steroidal Supramolecular Gels Designed for Drug Release." Molecules 18, no. 4: 3745-3759.