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Molecules 2013, 18(6), 7323-7335; doi:10.3390/molecules18067323
Article

Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats

1,2,3
, 1
, 1,4
, 1,2
, 5
 and 1,3,6,*
1 Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan 2 Department of Urology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan 3 Department of Education and Research, Taipei City Hospital, Taipei 10341, Taiwan 4 National Research Institute of Chinese Medicine, Taipei 11221, Taiwan 5 Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 11221, Taiwan 6 Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 April 2013 / Revised: 16 May 2013 / Accepted: 19 June 2013 / Published: 21 June 2013
(This article belongs to the Section Metabolites)
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Abstract

Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromatography. The rat plasma was sampled from each anesthetized rat after pretreatment with 3-days Epimedium sagittatum extract (1/2 g/kg/day) and intravenous injection with sildenafil (10/30 mg/kg). The pharmacokinetic data demonstrate that the area under the concentration-time curve (AUC) of sildenafil (10 mg/kg) was significantly decreased in groups that received a high dose of Epimedium sagittatum extract. In conclusion, the study demonstrates that there was significant herb-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil at low and high daily doses, suggesting co-administration use of Epimedium sagittatum extract and sildenafil in clinical practice should be prevented due to possible herb-drug interactions.
Keywords: sildenafil; Epimedium sagittatum extract; herb-drug interaction; Traditional Chinese Medicine sildenafil; Epimedium sagittatum extract; herb-drug interaction; Traditional Chinese Medicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hsueh, T.Y.; Wu, Y.-T.; Lin, L.-C.; Chiu, A.W.; Lin, C.-H.; Tsai, T.-H. Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats. Molecules 2013, 18, 7323-7335.

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