Molecules 2013, 18(6), 7309-7322; doi:10.3390/molecules18067309
Article

Monoterpenoid Indole Alkaloids from Alstonia rupestris with Cytotoxic, Anti-Inflammatory and Antifungal Activities

1,†, 2,† and 3,*
Received: 22 April 2013; in revised form: 3 June 2013 / Accepted: 9 June 2013 / Published: 21 June 2013
(This article belongs to the Section Metabolites)
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Abstract: Phytochemical investigation of the 70% EtOH extract of the leaves of Alstonia scholaris afforded seven new monoterpenoid indole alkaloids: scholarisins I-VII (1-7), and three known compounds: (3R,5S,7R,15R,16R,19E)-scholarisine F (8), 3-epi-dihydro- corymine (9), and (E)-16-formyl-5α-methoxystrictamine (10). Structural elucidation of all the compounds was accomplished by spectral methods such as 1D- and 2D-NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxicity against seven tumor cell lines, anti-inflammatory activities against Cox-1 and Cox-2, and antifungal potential against five species of fungi. Compounds 1, 6, and 10 exhibited significant cytotoxicities against all the tested tumor cell lines with IC50 values of less than 30 μM and selective inhibition of Cox-2 comparable with the standard drug NS-398 (>90%). Additionally, 1, 2, 3 and 8 showed antifungal activity against two fungal strains (G. pulicaris and C. nicotianae).
Keywords: Alstonia rupestris; Apocynaceae; monoterpenoid indole alkaloids; cytotoxicity; anti-inflammatory; antifungal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, W.; Cheng, M.-H.; Wang, X.-H. Monoterpenoid Indole Alkaloids from Alstonia rupestris with Cytotoxic, Anti-Inflammatory and Antifungal Activities. Molecules 2013, 18, 7309-7322.

AMA Style

Wang W, Cheng M-H, Wang X-H. Monoterpenoid Indole Alkaloids from Alstonia rupestris with Cytotoxic, Anti-Inflammatory and Antifungal Activities. Molecules. 2013; 18(6):7309-7322.

Chicago/Turabian Style

Wang, Wei; Cheng, Ming-He; Wang, Xiao-Hua. 2013. "Monoterpenoid Indole Alkaloids from Alstonia rupestris with Cytotoxic, Anti-Inflammatory and Antifungal Activities." Molecules 18, no. 6: 7309-7322.


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