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Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Tianmu College, Zhejiang Agriculture and Forestry University, Linan 311300, China
* Authors to whom correspondence should be addressed.
Received: 22 April 2013; in revised form: 14 June 2013 / Accepted: 18 June 2013 / Published: 24 June 2013
Abstract: Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC50 of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme.
Keywords: Tabebuia avellanedae Lorentz ex Griseb; phenylpropanoid glycosides; antioxidant activity
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Suo, M.; Ohta, T.; Takano, F.; Jin, S. Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae. Molecules 2013, 18, 7336-7345.
Suo M, Ohta T, Takano F, Jin S. Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae. Molecules. 2013; 18(7):7336-7345.
Suo, Maorong; Ohta, Tomihisa; Takano, Fumihide; Jin, Shouwen. 2013. "Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae." Molecules 18, no. 7: 7336-7345.