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Molecules 2013, 18(4), 4181-4191; doi:10.3390/molecules18044181
Article

Yellow Pigments, Fomitellanols A and B, and Drimane Sesquiterpenoids, Cryptoporic Acids P and Q, from Fomitella fraxinea and Their Inhibitory Activity against COX and 5-LO

* , , , , , ,  and
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan
* Author to whom correspondence should be addressed.
Received: 25 February 2013 / Revised: 28 March 2013 / Accepted: 4 April 2013 / Published: 9 April 2013
(This article belongs to the Section Metabolites)
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Abstract

Yellow pigments, fomitellanols A (1a) and B (2a), and drimane-type sesquiterpenoid ethers of isocitric acid, cryptoporic acids P (3) and Q (4), have been isolated from the fruiting bodies of Fomitella fraxinea (Polyporaceae). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses, and their biological activity against COX-1, COX-2, and 5-LO was investigated.
Keywords: Fomitella fraxinea; Polyporaceae; fomitellanol; cryptoporic acid; cyclooxygenase-1 (COX-1) and COX-2; 5-lipoxygenase (5-LO) Fomitella fraxinea; Polyporaceae; fomitellanol; cryptoporic acid; cyclooxygenase-1 (COX-1) and COX-2; 5-lipoxygenase (5-LO)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yoshikawa, K.; Koso, K.; Shimomura, M.; Tanaka, M.; Yamamoto, H.; Imagawa, H.; Arihara, S.; Hashimoto, T. Yellow Pigments, Fomitellanols A and B, and Drimane Sesquiterpenoids, Cryptoporic Acids P and Q, from Fomitella fraxinea and Their Inhibitory Activity against COX and 5-LO. Molecules 2013, 18, 4181-4191.

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