Molecules 2013, 18(4), 4192-4208; doi:10.3390/molecules18044192
Article

Comparative Study on the Larvicidal Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Drosophila melanogaster til-til

1 Departamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, Valparaíso 2340000, Chile 2 Departamento de Ciencias Básicas, Universidad del Biobío, Campus Fernando May, Avda. Andrés Bello s/n casilla 447, Chillán 3780000, Chile 3 Escuela de Medicina, Centro de Investigaciones Biomédicas (CIB), Universidad de Valparaíso, Av. Hontaneda N° 2664, Valparaíso 234000, Chile 4 Facultad de Farmacia, Universidad de Valparaíso, Av. Gran Bretaña N° 1093, Valparaíso 234000, Chile
* Authors to whom correspondence should be addressed.
Received: 16 February 2013; in revised form: 7 March 2013 / Accepted: 1 April 2013 / Published: 10 April 2013
(This article belongs to the Section Natural Products)
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Abstract: Natural compounds from Drimys winteri Forst and derivatives exhibited larvicidal effects against Drosophila melanogaster til-til. The most active compound was isodrimenin (4). The highest lethal concentration to the larvae of D. melanogaster was 4.5 ± 0.8 mg/L. At very low concentrations drimenol (1), confertifolin (3), and drimanol (5) displayed antifeedant and larvae growth regulatory activity. The antifeedant results of nordrimanic and drimanic compounds were better in first instar larvae. The EC50 value of polygodial (2) was 60.0 ± 4.2 mg/L; of diol 15 45.0 ± 2.8 mg/L, and of diol 17 36.9 ± 3.7 mg/L, while the new nordrimane compound 12 presented a value of 83.2 ± 3.5 mg/L.
Keywords: antifeedant activity; Drosophila melanogaster til-til; nordrimanes; drimanes; sesquiterpenes

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MDPI and ACS Style

Montenegro, I.; Pino, L.; Werner, E.; Madrid, A.; Espinoza, L.; Moreno, L.; Villena, J.; Cuellar, M. Comparative Study on the Larvicidal Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Drosophila melanogaster til-til. Molecules 2013, 18, 4192-4208.

AMA Style

Montenegro I, Pino L, Werner E, Madrid A, Espinoza L, Moreno L, Villena J, Cuellar M. Comparative Study on the Larvicidal Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Drosophila melanogaster til-til. Molecules. 2013; 18(4):4192-4208.

Chicago/Turabian Style

Montenegro, Ivan; Pino, Luis; Werner, Enrique; Madrid, Alejandro; Espinoza, Luis; Moreno, Luis; Villena, Joan; Cuellar, Mauricio. 2013. "Comparative Study on the Larvicidal Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Drosophila melanogaster til-til." Molecules 18, no. 4: 4192-4208.

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