Molecules 2013, 18(4), 4170-4180; doi:10.3390/molecules18044170
Article

Chemical Composition and Nematicidal Activity of Essential Oil of Agastache rugosa against Meloidogyne incognita

1 Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China 2 College of Resources Science and Technology, Beijing Normal University, Haidian District, Beijing 100875, China 3 Analytic and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China
* Authors to whom correspondence should be addressed.
Received: 26 February 2013; in revised form: 2 April 2013 / Accepted: 3 April 2013 / Published: 9 April 2013
(This article belongs to the Section Natural Products)
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Abstract: The aim of this research was to determine the chemical composition and nematicidal activity of essential oil of Agastache rugosa flowering aerial parts against the root knot nematode, Meloidogyne incognita, and to isolate and identify any nematicidal constituents from the essential oil. The essential oil of A. rugosa aerial parts was obtained by hydrodistillation and analyzed by GC-FID and GC-MS. A total of 37 components of the essential oil were identified, with the principal compounds being methyleugenol (50.51%), estragole (8.55%), and eugenol (7.54%), followed by thymol (3.62%), pulegone (2.56%), limonene (2.49%) and caryophyllene (2.38%). Based on bioactivity-guided fractionation, the three active constituents were isolated from the essential oil and identified as methyleugenol, estragole and eugenol. The essential oil of A. rugosa exhibited strong nematicidal activity against M. incognita, with a LC50 value of 47.3 μg/mL. The components eugenol (LC50 = 66.6 μg/mL) and methyleugenol (LC50 = 89.4 μg/mL) exhibited stronger nematicidal activity against M. incognita (LC50 = 185.9 μg/mL). The results indicate that the essential oil of A. rugosa aerial parts and its constituent compounds have potential for development into natural nematicides for control of the root knot nematode.
Keywords: Agastache rugosa; Meloidogyne incognita; essential oil composition; methyleugenol; estragole; eugenol

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MDPI and ACS Style

Li, H.Q.; Liu, Q.Z.; Liu, Z.L.; Du, S.S.; Deng, Z.W. Chemical Composition and Nematicidal Activity of Essential Oil of Agastache rugosa against Meloidogyne incognita. Molecules 2013, 18, 4170-4180.

AMA Style

Li HQ, Liu QZ, Liu ZL, Du SS, Deng ZW. Chemical Composition and Nematicidal Activity of Essential Oil of Agastache rugosa against Meloidogyne incognita. Molecules. 2013; 18(4):4170-4180.

Chicago/Turabian Style

Li, He Q.; Liu, Qi Z.; Liu, Zhi L.; Du, Shu S.; Deng, Zhi W. 2013. "Chemical Composition and Nematicidal Activity of Essential Oil of Agastache rugosa against Meloidogyne incognita." Molecules 18, no. 4: 4170-4180.

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