Next Article in Journal
Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors
Next Article in Special Issue
Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus
Previous Article in Journal
Synthesis and Characterization of Celecoxib Derivatives as Possible Anti-Inflammatory, Analgesic, Antioxidant, Anticancer and Anti-HCV Agents
Previous Article in Special Issue
Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(3), 3615-3629; doi:10.3390/molecules18033615

Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters

Department of Applied Chemistry, China Agricultural University, Beijing 100193, China
Author to whom correspondence should be addressed.
Received: 4 February 2013 / Revised: 14 March 2013 / Accepted: 15 March 2013 / Published: 21 March 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
View Full-Text   |   Download PDF [225 KB, uploaded 18 June 2014]   |  


In order to develop potential glucosamine-6-phosphate synthase inhibitors and anti-fungal agents, twenty five oleanolic acid oxime esters were synthesized in an efficient way. The structures of the new compounds were confirmed by MS, HRMS, 1H-NMR and 13C-NMR. Preliminary studies based on means of the Elson-Morgan method indicated that many compounds exhibited some inhibitory activity of glucosamine-6-phosphate synthase (GlmS), and the original fungicidal activities results showed that some of the compounds exhibited good fungicidal activities towards Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn and Botrytis cinerea Pers at the concentration of 50 µg/mL. These compounds would thus merit further study and development as antifungal agents.
Keywords: oleanolic acid; oxime ester; glucosamine-6-phosphate synthase; anti-fungal activity oleanolic acid; oxime ester; glucosamine-6-phosphate synthase; anti-fungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhao, H.; Zhou, M.; Duan, L.; Wang, W.; Zhang, J.; Wang, D.; Liang, X. Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters. Molecules 2013, 18, 3615-3629.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top