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Molecules 2013, 18(3), 3630-3640; doi:10.3390/molecules18033630
Article

Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors

, , , , , * , * ,  and
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 6 January 2013 / Revised: 14 March 2013 / Accepted: 18 March 2013 / Published: 21 March 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8–12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.
Keywords: synthesis; EV 71; N-phenylbenzamide synthesis; EV 71; N-phenylbenzamide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ji, X.-Y.; Wang, H.-Q.; Hao, L.-H.; He, W.-Y.; Gao, R.-M.; Li, Y.-P.; Li, Y.-H.; Jiang, J.-D.; Li, Z.-R. Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors. Molecules 2013, 18, 3630-3640.

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