Molecules 2013, 18(3), 3630-3640; doi:10.3390/molecules18033630
Article

Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 6 January 2013; in revised form: 14 March 2013 / Accepted: 18 March 2013 / Published: 21 March 2013
(This article belongs to the Section Medicinal Chemistry)
PDF Full-text Download PDF Full-Text [232 KB, uploaded 21 March 2013 12:30 CET]
Abstract: A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8–12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.
Keywords: synthesis; EV 71; N-phenylbenzamide

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Ji, X.-Y.; Wang, H.-Q.; Hao, L.-H.; He, W.-Y.; Gao, R.-M.; Li, Y.-P.; Li, Y.-H.; Jiang, J.-D.; Li, Z.-R. Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors. Molecules 2013, 18, 3630-3640.

AMA Style

Ji X-Y, Wang H-Q, Hao L-H, He W-Y, Gao R-M, Li Y-P, Li Y-H, Jiang J-D, Li Z-R. Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors. Molecules. 2013; 18(3):3630-3640.

Chicago/Turabian Style

Ji, Xing-Yue; Wang, Hui-Qiang; Hao, Lan-Hu; He, Wei-Ying; Gao, Rong-Mei; Li, Yan-Ping; Li, Yu-Huan; Jiang, Jian-Dong; Li, Zhuo-Rong. 2013. "Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors." Molecules 18, no. 3: 3630-3640.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert