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Molecules 2013, 18(4), 3725-3732; doi:10.3390/molecules18043725
Communication

Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

1, 1, 1, 1, 2, 1, 1, 1, 1 and 1,*
Received: 1 February 2013; in revised form: 19 March 2013 / Accepted: 20 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
Download PDF [297 KB, uploaded 18 June 2014]
Abstract: A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lee, D.-Y.; Noh, H.-J.; Choi, J.; Lee, K.-H.; Lee, M.-H.; Lee, J.-H.; Hong, Y.; Lee, S.-E.; Kim, S.-Y.; Kim, G.-S. Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus. Molecules 2013, 18, 3725-3732.

AMA Style

Lee D-Y, Noh H-J, Choi J, Lee K-H, Lee M-H, Lee J-H, Hong Y, Lee S-E, Kim S-Y, Kim G-S. Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus. Molecules. 2013; 18(4):3725-3732.

Chicago/Turabian Style

Lee, Dae-Young; Noh, Hyung-Jun; Choi, Jehun; Lee, Kyeong-Hee; Lee, Min-Ho; Lee, Ji-Hyun; Hong, Yoonpyo; Lee, Seung-Eun; Kim, Seung-Yu; Kim, Geum-Soog. 2013. "Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus." Molecules 18, no. 4: 3725-3732.


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