Next Article in Journal
Synthesis of Structured Lipids by Lipase-Catalyzed Interesterification of Triacetin with Camellia Oil Methyl Esters and Preliminary Evaluation of their Plasma Lipid-Lowering Effect in Mice
Next Article in Special Issue
Steroidal Triterpenes of Cholesterol Synthesis
Previous Article in Journal
Microwave Assisted Suzuki-Miyaura and Ullmann Type Homocoupling Reactions of 2- and 3-Halopyridines Using a Pd(OAc)2/Benzimidazolium Salt and Base Catalyst System
Previous Article in Special Issue
Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters
Molecules 2013, 18(4), 3725-3732; doi:10.3390/molecules18043725

Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

1, 1, 1, 1, 2, 1, 1, 1, 1 and 1,*
1 Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea 2 Department of Food Technology and Services, Eulji University, Seongnam 461-723, Korea
* Author to whom correspondence should be addressed.
Received: 1 February 2013 / Revised: 19 March 2013 / Accepted: 20 March 2013 / Published: 25 March 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
Download PDF [297 KB, uploaded 18 June 2014]


A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary material

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Lee, D.-Y.; Noh, H.-J.; Choi, J.; Lee, K.-H.; Lee, M.-H.; Lee, J.-H.; Hong, Y.; Lee, S.-E.; Kim, S.-Y.; Kim, G.-S. Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus. Molecules 2013, 18, 3725-3732.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert