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Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus
Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-873, Korea
Department of Food Technology and Services, Eulji University, Seongnam 461-723, Korea
* Author to whom correspondence should be addressed.
Received: 1 February 2013; in revised form: 19 March 2013 / Accepted: 20 March 2013 / Published: 25 March 2013
Abstract: A new cycloartane-type triterpene glycoside, agroastragaloside V (1) was isolated from the roots of Astragalus membranaceus. The structure was identified as 3-O-β-(2'-O-acetyl)-D-xylopyranosyl-6-O-β-D-glucopyranosyl-(24S)-3β,6α,24α,25-tetrahydroxy- 9,19-cyclolanostane, by means of spectroscopic methods, including HR-FAB/MS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. Four known cycloartane glycosides, namely, agroastragaloside I (2), agroastragaloside II (3), isoastragaloside II (4) and astragaloside IV (5) were also isolated. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Keywords: Astragalus membranaceus; cycloartane-type triterpene; agroastragaloside V; nitric oxide
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Lee, D.-Y.; Noh, H.-J.; Choi, J.; Lee, K.-H.; Lee, M.-H.; Lee, J.-H.; Hong, Y.; Lee, S.-E.; Kim, S.-Y.; Kim, G.-S. Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus. Molecules 2013, 18, 3725-3732.
Lee D-Y, Noh H-J, Choi J, Lee K-H, Lee M-H, Lee J-H, Hong Y, Lee S-E, Kim S-Y, Kim G-S. Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus. Molecules. 2013; 18(4):3725-3732.
Lee, Dae-Young; Noh, Hyung-Jun; Choi, Jehun; Lee, Kyeong-Hee; Lee, Min-Ho; Lee, Ji-Hyun; Hong, Yoonpyo; Lee, Seung-Eun; Kim, Seung-Yu; Kim, Geum-Soog. 2013. "Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus." Molecules 18, no. 4: 3725-3732.