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Molecules 2013, 18(2), 1720-1727; doi:10.3390/molecules18021720
Article

Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke

1, 1, 1, 1, 2, 3 and 1,*
Received: 19 December 2012 / Revised: 18 January 2013 / Accepted: 18 January 2013 / Published: 29 January 2013
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Abstract

Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 14) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 13 showed moderate cytotoxity against HeLa cells, with IC50 values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala.
Keywords: Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tian, X.; Ding, G.; Peng, C.; Hu, Y.; Li, L.; Chen, H.; Zou, Z. Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke. Molecules 2013, 18, 1720-1727.

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