Molecules 2013, 18(2), 1720-1727; doi:10.3390/molecules18021720
Article

Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke

Xinhui Tian 1 , Gang Ding 1 , Chaozhong Peng 1 , Yanbao Hu 1 , Li Li 2 , Hong Chen 3  and Zhongmei Zou 1,* email
1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 2 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China 3 Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard, Department of Pharmacognosy, Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, China
* Author to whom correspondence should be addressed.
Received: 19 December 2012; in revised form: 18 January 2013 / Accepted: 18 January 2013 / Published: 29 January 2013
PDF Full-text Download PDF Full-Text [259 KB, uploaded 29 January 2013 08:23 CET]
Abstract: Four new sinapyl alcohol derivatives dichrocephols A–D (compounds 1–4) were isolated from the lipo-soluble part of the whole herb of Dichrocephala benthamii C. B. Clarke, together with the known compound syringenin isovalerate (5). Their structures were elucidated on the basis of spectroscopic analysis. Their absolute configurations were established by the method of alkaline hydrohysis. Compounds 1–3 showed moderate cytotoxity against HeLa cells, with IC50 values of 14.8 μM, 51.6 μM and 81.6 μM, respectively. This is the first time that sinapyl alcohol derivatives were isolated from the genus Dichrocephala.
Keywords: Dichrocephala benthamii C. B. Clarke; Asteraceae; sinapyl alcohol derivatives; absolute configuration determination; cytotoxicity

Supplementary Files

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Tian, X.; Ding, G.; Peng, C.; Hu, Y.; Li, L.; Chen, H.; Zou, Z. Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke. Molecules 2013, 18, 1720-1727.

AMA Style

Tian X, Ding G, Peng C, Hu Y, Li L, Chen H, Zou Z. Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke. Molecules. 2013; 18(2):1720-1727.

Chicago/Turabian Style

Tian, Xinhui; Ding, Gang; Peng, Chaozhong; Hu, Yanbao; Li, Li; Chen, Hong; Zou, Zhongmei. 2013. "Sinapyl Alcohol Derivatives from the Lipo-soluble Part of Dichrocephala benthamii C. B. Clarke." Molecules 18, no. 2: 1720-1727.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert