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Chemical Genetics of Acetyl-CoA Carboxylases
Institute of Clinical Medicine, the First Affiliated Hospital, University of South China, Hengyang 421001, Hunan, China
Institute of Translational Medicine & Department of Laboratory Medicine, the First People's Hospital of Chenzhou, 102 Luojiajing Road, Chenzhou 423000, Hunan, China
Department of Microbiology, Immunology and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, Springfield, IL 62794, USA
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 August 2012; in revised form: 3 January 2013 / Accepted: 11 January 2013 / Published: 28 January 2013
Abstract: Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers.
Keywords: acetyl-CoA carboxylase; fatty acid biosynthesis; ACC chemical genetics; ACC inhibitors; cancer therapy
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MDPI and ACS Style
Zu, X.; Zhong, J.; Luo, D.; Tan, J.; Zhang, Q.; Wu, Y.; Liu, J.; Cao, R.; Wen, G.; Cao, D. Chemical Genetics of Acetyl-CoA Carboxylases. Molecules 2013, 18, 1704-1719.
Zu X, Zhong J, Luo D, Tan J, Zhang Q, Wu Y, Liu J, Cao R, Wen G, Cao D. Chemical Genetics of Acetyl-CoA Carboxylases. Molecules. 2013; 18(2):1704-1719.
Zu, Xuyu; Zhong, Jing; Luo, Dixian; Tan, Jingjing; Zhang, Qinghai; Wu, Ying; Liu, Jianghua; Cao, Renxian; Wen, Gebo; Cao, Deliang. 2013. "Chemical Genetics of Acetyl-CoA Carboxylases." Molecules 18, no. 2: 1704-1719.