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Molecules 2013, 18(2), 1704-1719; doi:10.3390/molecules18021704

Chemical Genetics of Acetyl-CoA Carboxylases

1,†, 1,†, 2, 1, 1, 1, 1, 1,* , 1 and 3,*
Received: 3 August 2012 / Revised: 3 January 2013 / Accepted: 11 January 2013 / Published: 28 January 2013
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Abstract: Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers.
Keywords: acetyl-CoA carboxylase; fatty acid biosynthesis; ACC chemical genetics; ACC inhibitors; cancer therapy acetyl-CoA carboxylase; fatty acid biosynthesis; ACC chemical genetics; ACC inhibitors; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zu, X.; Zhong, J.; Luo, D.; Tan, J.; Zhang, Q.; Wu, Y.; Liu, J.; Cao, R.; Wen, G.; Cao, D. Chemical Genetics of Acetyl-CoA Carboxylases. Molecules 2013, 18, 1704-1719.

AMA Style

Zu X, Zhong J, Luo D, Tan J, Zhang Q, Wu Y, Liu J, Cao R, Wen G, Cao D. Chemical Genetics of Acetyl-CoA Carboxylases. Molecules. 2013; 18(2):1704-1719.

Chicago/Turabian Style

Zu, Xuyu; Zhong, Jing; Luo, Dixian; Tan, Jingjing; Zhang, Qinghai; Wu, Ying; Liu, Jianghua; Cao, Renxian; Wen, Gebo; Cao, Deliang. 2013. "Chemical Genetics of Acetyl-CoA Carboxylases." Molecules 18, no. 2: 1704-1719.

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