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Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones
Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, complesso universitario di Monserrato, S.S. 554, bivio per Sestu, Monserrato 09042, CA, Italy
* Author to whom correspondence should be addressed.
Received: 7 November 2013; in revised form: 9 December 2013 / Accepted: 11 December 2013 / Published: 13 December 2013
Abstract: In the last decade a certain number of new cyclobutane and cyclobutanone synthesis and functionalization protocols have been published. Organo- and biocatalyzed eco-friendly approaches to cyclobutane-containing molecules have been developed with interesting results. Also, successful new total synthesis of bioactive compounds and drugs have been recently reported where a four membered ring represented the key intermediate. Therefore, the rising interest in this field represents a great point of discussion for the scientific community, disclosing the synthetic potential of strained four membered ring carbocyclic compounds. Herein we report a critical survey on the literature concerning the enantiocontrolled synthesis and functionalization of cyclobutane derivatives, with particular attention to metal-free, low impact methodologies, published during the period 2000–2013.
Keywords: cyclobutanone; cyclobutane; stereocontrol; ring enlargement; alkylation; organocatalysis; cycloaddition; biocatalysis; stereochemistry; oxidation
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MDPI and ACS Style
Secci, F.; Frongia, A.; Piras, P.P. Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones. Molecules 2013, 18, 15541-15572.
Secci F, Frongia A, Piras PP. Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones. Molecules. 2013; 18(12):15541-15572.
Secci, Francesco; Frongia, Angelo; Piras, Pier P. 2013. "Stereocontrolled Synthesis and Functionalization of Cyclobutanes and Cyclobutanones." Molecules 18, no. 12: 15541-15572.