Molecules 2013, 18(12), 14529-14542; doi:10.3390/molecules181214529
Article

Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones

1 Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan 2 Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan
* Author to whom correspondence should be addressed.
Received: 30 October 2013; in revised form: 20 November 2013 / Accepted: 21 November 2013 / Published: 25 November 2013
(This article belongs to the Special Issue Dynamic Stereochemistry)
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Abstract: Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee.
Keywords: organocatalyst; sulfonamide; vinyl sulfone; conjugate addition; quaternary stereocenters; fluorous

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MDPI and ACS Style

Nakashima, K.; Murahashi, M.; Yuasa, H.; Ina, M.; Tada, N.; Itoh, A.; Hirashima, S.-I.; Koseki, Y.; Miura, T. Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones. Molecules 2013, 18, 14529-14542.

AMA Style

Nakashima K, Murahashi M, Yuasa H, Ina M, Tada N, Itoh A, Hirashima S-I, Koseki Y, Miura T. Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones. Molecules. 2013; 18(12):14529-14542.

Chicago/Turabian Style

Nakashima, Kosuke; Murahashi, Miho; Yuasa, Hiroki; Ina, Mariko; Tada, Norihiro; Itoh, Akichika; Hirashima, Shin-ichi; Koseki, Yuji; Miura, Tsuyoshi. 2013. "Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones." Molecules 18, no. 12: 14529-14542.

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