Molecules 2013, 18(12), 14543-14563; doi:10.3390/molecules181214543
Article

Evaluation of Sulfated Polysaccharides from the Brown Seaweed Dictyopteris Justii as Antioxidant Agents and as Inhibitors of the Formation of Calcium Oxalate Crystals

1 Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte 59072-970, Brazil 2 Instituto de Química, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte 59072-970, Brazil
* Author to whom correspondence should be addressed.
Received: 8 October 2013; in revised form: 8 November 2013 / Accepted: 12 November 2013 / Published: 25 November 2013
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Abstract: Oxalate crystals and other types of crystals are the cause of urolithiasis, and these are related to oxidative stress. The search for new compounds with antioxidant qualities and inhibitors of these crystal formations is therefore necessary. In this study, we extracted four sulfated polysaccharides, a fucoglucoxyloglucuronan (DJ-0.3v), a heterofucan (DJ-0.4v), and two glucans (DJ-0.5v and DJ-1.2v), from the marine alga Dictyopteris justii. The presence of sulfated polysaccharides was confirmed by chemical analysis and FT-IR. All the sulfated polysaccharides presented antioxidant activity under different conditions in some of the in vitro tests and inhibited the formation of calcium oxalate crystals. Fucan DJ-0.4v was the polysaccharide that showed the best antioxidant activity and was one of the best inhibitors of the crystallization of calcium oxalate. Glucan DJ-0.5v was the second most potent inhibitor of the formation of oxalate crystals, as it stabilized dehydrated oxalate crystals (less aggressive form), preventing them from transforming into monohydrate crystals (more aggressive form). The obtained data lead us to propose that these sulfated polysaccharides are promising agents for use in the treatment of urolithiasis.
Keywords: fucan; glucan; urolithiasis; bioactive polysaccharides

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MDPI and ACS Style

Teodosio Melo, K.R.; Gomes Camara, R.B.; Queiroz, M.F.; Jacome Vidal, A.A.; Machado Lima, C.R.; Melo-Silveira, R.F.; Almeida-Lima, J.; Oliveira Rocha, H.A. Evaluation of Sulfated Polysaccharides from the Brown Seaweed Dictyopteris Justii as Antioxidant Agents and as Inhibitors of the Formation of Calcium Oxalate Crystals. Molecules 2013, 18, 14543-14563.

AMA Style

Teodosio Melo KR, Gomes Camara RB, Queiroz MF, Jacome Vidal AA, Machado Lima CR, Melo-Silveira RF, Almeida-Lima J, Oliveira Rocha HA. Evaluation of Sulfated Polysaccharides from the Brown Seaweed Dictyopteris Justii as Antioxidant Agents and as Inhibitors of the Formation of Calcium Oxalate Crystals. Molecules. 2013; 18(12):14543-14563.

Chicago/Turabian Style

Teodosio Melo, Karoline R.; Gomes Camara, Rafael B.; Queiroz, Moacir F.; Jacome Vidal, Arthur A.; Machado Lima, Camila R.; Melo-Silveira, Raniere F.; Almeida-Lima, Jailma; Oliveira Rocha, Hugo A. 2013. "Evaluation of Sulfated Polysaccharides from the Brown Seaweed Dictyopteris Justii as Antioxidant Agents and as Inhibitors of the Formation of Calcium Oxalate Crystals." Molecules 18, no. 12: 14543-14563.

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