Molecules 2013, 18(11), 13124-13138; doi:10.3390/molecules181113124
Review

Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)

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Received: 28 August 2013; in revised form: 23 September 2013 / Accepted: 25 September 2013 / Published: 24 October 2013
(This article belongs to the Special Issue Steroids)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Different strategies for the racemic or enantiospecific total syntheses of plant and mammalian 3,4-dibenzyltetrahydrofuran lignans are reviewed and compared. The multi-step approaches have various key step strategies: Diels–Alder reactions, Stobbe condensations, Michael additions, alkylations, nitrile oxide cycloadditions, radical cyclisations, dianion and oxidative couplings.
Keywords: lignan; trans-3,4-dibenzyltetrahydrofuran; tetrahydrofuran; 9,9'-epoxylignane; synthesis
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MDPI and ACS Style

Pohjoispää, M.; Wähälä, K. Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes). Molecules 2013, 18, 13124-13138.

AMA Style

Pohjoispää M, Wähälä K. Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes). Molecules. 2013; 18(11):13124-13138.

Chicago/Turabian Style

Pohjoispää, Monika; Wähälä, Kristiina. 2013. "Synthesis of 3,4-Dibenzyltetrahydrofuran Lignans (9,9′-Epoxylignanes)." Molecules 18, no. 11: 13124-13138.

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