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Molecules 2013, 18(11), 13139-13147; doi:10.3390/molecules181113139
Article

Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives

, *  and
School of Safety Engineering, China University of Mining &Technology, Xuzhou 221116, Jiangsu, China
* Author to whom correspondence should be addressed.
Received: 27 September 2013 / Revised: 16 October 2013 / Accepted: 16 October 2013 / Published: 24 October 2013
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Abstract

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum’s acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.
Keywords: pyrazolo[3,4-b]pyridine-6(7H)-one; recyclable polyethylene glycol; aqueous media; synthesis pyrazolo[3,4-b]pyridine-6(7H)-one; recyclable polyethylene glycol; aqueous media; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhong, X.; Dou, G.; Wang, D. Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives. Molecules 2013, 18, 13139-13147.

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