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Molecules 2013, 18(11), 13139-13147; doi:10.3390/molecules181113139
Article

Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives

, *  and
School of Safety Engineering, China University of Mining &Technology, Xuzhou 221116, Jiangsu, China
* Author to whom correspondence should be addressed.
Received: 27 September 2013 / Revised: 16 October 2013 / Accepted: 16 October 2013 / Published: 24 October 2013
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Abstract

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum’s acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.
Keywords: pyrazolo[3,4-b]pyridine-6(7H)-one; recyclable polyethylene glycol; aqueous media; synthesis pyrazolo[3,4-b]pyridine-6(7H)-one; recyclable polyethylene glycol; aqueous media; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhong, X.; Dou, G.; Wang, D. Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives. Molecules 2013, 18, 13139-13147.

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