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Molecules 2013, 18(10), 12264-12289; doi:10.3390/molecules181012264
Review

Schiff Bases: A Short Survey on an Evergreen Chemistry Tool

1
, 1
, 2,*  and 3,*
1 Dipartimento di Chimica "G. Ciamician" Via Selmi 2, Bologna 40126, Italy 2 ISOF-CNR Dipartimento di Chimica "G. Ciamician" Via Selmi 2, Bologna 40126, Italy 3 Allecra Therapeutics SAS, 13, Rue du Village Neuf, Saint Louis 68300, France
* Authors to whom correspondence should be addressed.
Received: 10 August 2013 / Revised: 18 September 2013 / Accepted: 23 September 2013 / Published: 8 October 2013
(This article belongs to the Special Issue Named Organic Reactions based on Italian Chemists)
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Abstract

The review reports a short biography of the Italian naturalized chemist Hugo Schiff and an outline on the synthesis and use of his most popular discovery: the imines, very well known and popular as Schiff Bases. Recent developments on their “metallo-imines” variants have been described. The applications of Schiff bases in organic synthesis as partner in Staudinger and hetero Diels-Alder reactions, as “privileged” ligands in the organometallic complexes and as biological active Schiff intermediates/targets have been reported as well.
Keywords: imines; Schiff bases; metallo-imines; salen complexes; bio-active-imines imines; Schiff bases; metallo-imines; salen complexes; bio-active-imines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Qin, W.; Long, S.; Panunzio, M.; Biondi, S. Schiff Bases: A Short Survey on an Evergreen Chemistry Tool. Molecules 2013, 18, 12264-12289.

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