Molecules 2013, 18(10), 12119-12143; doi:10.3390/molecules181012119
Article

Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography

1 University of Vienna, Department of Drug and Natural Product Synthesis, Althanstraße 14, 1090 Vienna, Austria 2 Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria 3 Hospital Pharmacy of the General Hospital of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria 4 University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Althanstraße 14, 1090 Vienna, Austria 5 University of Vienna, Department of Inorganic Chemistry, Währinger Str. 42, 1090 Vienna, Austria
* Authors to whom correspondence should be addressed.
Received: 12 August 2013; in revised form: 22 September 2013 / Accepted: 22 September 2013 / Published: 30 September 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract: The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor′s eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [11C]SNAP-7941 and [18F]FE@SNAP. Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity.
Keywords: MCH receptor 1 (MCHR1); SNAP-7941; racSNAP-7941; positron emission tomography; adiposity

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MDPI and ACS Style

Schirmer, E.; Shanab, K.; Datterl, B.; Neudorfer, C.; Mitterhauser, M.; Wadsak, W.; Philippe, C.; Spreitzer, H. Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography. Molecules 2013, 18, 12119-12143.

AMA Style

Schirmer E, Shanab K, Datterl B, Neudorfer C, Mitterhauser M, Wadsak W, Philippe C, Spreitzer H. Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography. Molecules. 2013; 18(10):12119-12143.

Chicago/Turabian Style

Schirmer, Eva; Shanab, Karem; Datterl, Barbara; Neudorfer, Catharina; Mitterhauser, Markus; Wadsak, Wolfgang; Philippe, Cécile; Spreitzer, Helmut. 2013. "Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography." Molecules 18, no. 10: 12119-12143.

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