Next Article in Journal
Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography
Previous Article in Journal
Gaultheria: Phytochemical and Pharmacological Characteristics
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(10), 12109-12118; doi:10.3390/molecules181012109

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

1
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa., Cuernavaca 62209, Morelos, Mexico
2
Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa., Cuernavaca 62209, Morelos, Mexico
3
Instituto de Farmacobiología, Universidad de la Cañada, Carretera Teotitlán - San Antonio Nanahuatipán Km 1.7 s/n., Paraje Titlacuatitla, Teotitlán de Flores Magón 68540, Oax., Mexico
Taken in part from the Ph.D. thesis of Danae Carrillo-Ocampo.
*
Author to whom correspondence should be addressed.
Received: 23 July 2013 / Revised: 5 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [264 KB, 18 June 2014; original version 18 June 2014]   |  

Abstract

Castilleja tenuiflora (Orobanchaceae) has been used in Mexican traditional medicine as a treatment for cough, dysentery, anxiety, nausea and vomiting as well as hepatic and gastrointestinal diseases. The ethanolic extract of the aerial parts of Castilleja tenuiflora was separated by silica gel column chromatography. The fractions were evaluated using the induced edema acetate 12-O-tetradecanoylphorbol (TPA) anti-inflammatory activity model. The most active fraction was subjected to medium-pressure liquid chromatography (MPLC) with UV detection at 206 and 240 nm. The following iridoids were isolated: geniposidic acid, aucubin, bartioside, 8-epi-loganin, mussaenoside, and the phenylpropanoid verbascoside. The most active iridoid was geniposidic acid, which was more active than the control (indomethacin), and the least active iridoid was mussaenoside. 8-epi-Loganin, and mussaenoside have not been previously reported to be anti-inflammatory compounds. The results of these investigations confirm the potential of Mexican plants for the production of bioactive compounds and validate the ethnomedical use of Castilleja tenuiflora-like anti-inflammatory plants. View Full-Text
Keywords: Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Carrillo-Ocampo, D.; Bazaldúa-Gómez, S.; Bonilla-Barbosa, J.R.; Aburto-Amar, R.; Rodríguez-López, V. Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora. Molecules 2013, 18, 12109-12118.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top