Molecules 2013, 18(10), 12109-12118; doi:10.3390/molecules181012109
Article

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

1 Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa., Cuernavaca 62209, Morelos, Mexico 2 Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa., Cuernavaca 62209, Morelos, Mexico 3 Instituto de Farmacobiología, Universidad de la Cañada, Carretera Teotitlán - San Antonio Nanahuatipán Km 1.7 s/n., Paraje Titlacuatitla, Teotitlán de Flores Magón 68540, Oax., Mexico Taken in part from the Ph.D. thesis of Danae Carrillo-Ocampo.
* Author to whom correspondence should be addressed.
Received: 23 July 2013; in revised form: 5 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Natural Products)
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Abstract: Castilleja tenuiflora (Orobanchaceae) has been used in Mexican traditional medicine as a treatment for cough, dysentery, anxiety, nausea and vomiting as well as hepatic and gastrointestinal diseases. The ethanolic extract of the aerial parts of Castilleja tenuiflora was separated by silica gel column chromatography. The fractions were evaluated using the induced edema acetate 12-O-tetradecanoylphorbol (TPA) anti-inflammatory activity model. The most active fraction was subjected to medium-pressure liquid chromatography (MPLC) with UV detection at 206 and 240 nm. The following iridoids were isolated: geniposidic acid, aucubin, bartioside, 8-epi-loganin, mussaenoside, and the phenylpropanoid verbascoside. The most active iridoid was geniposidic acid, which was more active than the control (indomethacin), and the least active iridoid was mussaenoside. 8-epi-Loganin, and mussaenoside have not been previously reported to be anti-inflammatory compounds. The results of these investigations confirm the potential of Mexican plants for the production of bioactive compounds and validate the ethnomedical use of Castilleja tenuiflora-like anti-inflammatory plants.
Keywords: Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA

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MDPI and ACS Style

Carrillo-Ocampo, D.; Bazaldúa-Gómez, S.; Bonilla-Barbosa, J.R.; Aburto-Amar, R.; Rodríguez-López, V. Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora. Molecules 2013, 18, 12109-12118.

AMA Style

Carrillo-Ocampo D, Bazaldúa-Gómez S, Bonilla-Barbosa JR, Aburto-Amar R, Rodríguez-López V. Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora. Molecules. 2013; 18(10):12109-12118.

Chicago/Turabian Style

Carrillo-Ocampo, Danae; Bazaldúa-Gómez, Sugeyla; Bonilla-Barbosa, Jaime R.; Aburto-Amar, Rola; Rodríguez-López, Verónica. 2013. "Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora." Molecules 18, no. 10: 12109-12118.

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