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Molecules 2013, 18(10), 12109-12118; doi:10.3390/molecules181012109
Article

Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora

1,†, 1, 2
, 3
 and 1,*
Received: 23 July 2013; in revised form: 5 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013
(This article belongs to the Section Metabolites)
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Abstract: Castilleja tenuiflora (Orobanchaceae) has been used in Mexican traditional medicine as a treatment for cough, dysentery, anxiety, nausea and vomiting as well as hepatic and gastrointestinal diseases. The ethanolic extract of the aerial parts of Castilleja tenuiflora was separated by silica gel column chromatography. The fractions were evaluated using the induced edema acetate 12-O-tetradecanoylphorbol (TPA) anti-inflammatory activity model. The most active fraction was subjected to medium-pressure liquid chromatography (MPLC) with UV detection at 206 and 240 nm. The following iridoids were isolated: geniposidic acid, aucubin, bartioside, 8-epi-loganin, mussaenoside, and the phenylpropanoid verbascoside. The most active iridoid was geniposidic acid, which was more active than the control (indomethacin), and the least active iridoid was mussaenoside. 8-epi-Loganin, and mussaenoside have not been previously reported to be anti-inflammatory compounds. The results of these investigations confirm the potential of Mexican plants for the production of bioactive compounds and validate the ethnomedical use of Castilleja tenuiflora-like anti-inflammatory plants.
Keywords: Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Carrillo-Ocampo, D.; Bazaldúa-Gómez, S.; Bonilla-Barbosa, J.R.; Aburto-Amar, R.; Rodríguez-López, V. Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora. Molecules 2013, 18, 12109-12118.

AMA Style

Carrillo-Ocampo D, Bazaldúa-Gómez S, Bonilla-Barbosa JR, Aburto-Amar R, Rodríguez-López V. Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora. Molecules. 2013; 18(10):12109-12118.

Chicago/Turabian Style

Carrillo-Ocampo, Danae; Bazaldúa-Gómez, Sugeyla; Bonilla-Barbosa, Jaime R.; Aburto-Amar, Rola; Rodríguez-López, Verónica. 2013. "Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuiflora." Molecules 18, no. 10: 12109-12118.


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