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Molecules 2013, 18(1), 832-844; doi:10.3390/molecules18010832
Article

Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety

1, 2,†,*  and 1
Received: 31 October 2012 / Revised: 4 January 2013 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active methylene compounds producing pyran, pyridine and pyridazine derivatives. Also, the reactivity of the precursor hydrazone towards hydrazine derivatives to give pyrazole and oxazole derivatives was studied. On the other hand, treatment of the same precursor with urea, thiourea and/or guanidine hydrochloride furnished pyrimidine and thiazine derivatives, respectively. The newly synthesized compounds were tested for antibacterial activity, whereby eight compounds were found to have high activities.
Keywords: cyanoacetylhydrazide; sulfonamide; pyridazines; pyrazoles; oxazole; pyrimidines; antibacterial activity cyanoacetylhydrazide; sulfonamide; pyridazines; pyrazoles; oxazole; pyrimidines; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Azab, M.E.; Youssef, M.M.; El-Bordany, E.A. Synthesis and Antibacterial Evaluation of Novel Heterocyclic Compounds Containing a Sulfonamido Moiety. Molecules 2013, 18, 832-844.

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