‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

doi:10.3390/molecules18010814

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Molecules 2013, 18(1), 814-831; doi:10.3390/molecules18010814

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‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

Baifeng Jiang¹, Yu Zhou^2,* , Qingya Kong¹, Hualiang Jiang^1,2, Hong Liu² and Jian Li^1,*

¹ Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China ² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China

* Authors to whom correspondence should be addressed.

Received: 26 November 2012; in revised form: 4 January 2013 / Accepted: 5 January 2013 / Published: 11 January 2013

(This article belongs to the Section Organic Synthesis)

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Abstract: An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO₃ catalyzed ‘one-pot’ cascade process involving formation of two new C–N bonds and one new C–O bond.

Keywords: silver; one-pot; cascade transformation; isoquinolines; heterocyclic molecule

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Cite This Article

MDPI and ACS Style

Jiang, B.; Zhou, Y.; Kong, Q.; Jiang, H.; Liu, H.; Li, J. ‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach. Molecules 2013, 18, 814-831.

AMA Style

Jiang B, Zhou Y, Kong Q, Jiang H, Liu H, Li J. ‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach. Molecules. 2013; 18(1):814-831.

Chicago/Turabian Style

Jiang, Baifeng; Zhou, Yu; Kong, Qingya; Jiang, Hualiang; Liu, Hong; Li, Jian. 2013. "‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach." Molecules 18, no. 1: 814-831.

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