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Molecules 2013, 18(1), 814-831; doi:10.3390/molecules18010814
Article

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

1, 2,* , 1, 1,2, 2 and 1,*
1 Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China 2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
* Authors to whom correspondence should be addressed.
Received: 26 November 2012 / Revised: 4 January 2013 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Organic Synthesis)
Download PDF [318 KB, 18 June 2014; original version 18 June 2014]

Abstract

An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed ‘one-pot’ cascade process involving formation of two new C–N bonds and one new C–O bond.
Keywords: silver; one-pot; cascade transformation; isoquinolines; heterocyclic molecule silver; one-pot; cascade transformation; isoquinolines; heterocyclic molecule
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jiang, B.; Zhou, Y.; Kong, Q.; Jiang, H.; Liu, H.; Li, J. ‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach. Molecules 2013, 18, 814-831.

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