Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides

doi:10.3390/molecules18011063

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Molecules 2013, 18(1), 1063-1075; doi:10.3390/molecules18011063

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Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides

Tatyana Abramova^1,2

¹ Institute of Chemical Biology and Fundamental Medicine, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia ² Laboratory of Magnetic Resonance, Scientific Research Department, Novosibirsk State University, Pirogova St., 2, Novosibirsk 630090, Russia

Received: 18 December 2012; in revised form: 9 January 2013 / Accepted: 11 January 2013 / Published: 15 January 2013

(This article belongs to the Section Medicinal Chemistry)

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Abstract: The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed. Different problems concerning the methods and implementation of the ODN synthesis are outlined depending on goals of using target oligomers.

Keywords: parallel ODN synthesis; large-scale ODN synthesis; 5'-phosphorylated ODN; protective groups

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MDPI and ACS Style

Abramova, T. Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides. Molecules 2013, 18, 1063-1075.

AMA Style

Abramova T. Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides. Molecules. 2013; 18(1):1063-1075.

Chicago/Turabian Style

Abramova, Tatyana. 2013. "Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides." Molecules 18, no. 1: 1063-1075.

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