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Molecules 2013, 18(1), 1063-1075; doi:10.3390/molecules18011063
Review

Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides

1,2
1 Institute of Chemical Biology and Fundamental Medicine, Lavrent'ev Ave, 8, Novosibirsk 630090, Russia 2 Laboratory of Magnetic Resonance, Scientific Research Department, Novosibirsk State University, Pirogova St., 2, Novosibirsk 630090, Russia 
Received: 18 December 2012 / Revised: 9 January 2013 / Accepted: 11 January 2013 / Published: 15 January 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed. Different problems concerning the methods and implementation of the ODN synthesis are outlined depending on goals of using target oligomers.
Keywords: parallel ODN synthesis; large-scale ODN synthesis; 5'-phosphorylated ODN; protective groups parallel ODN synthesis; large-scale ODN synthesis; 5'-phosphorylated ODN; protective groups
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abramova, T. Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides. Molecules 2013, 18, 1063-1075.

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