Next Article in Journal
Effect of Acute and Fractionated Irradiation on Hippocampal Neurogenesis
Previous Article in Journal
Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(8), 9451-9461; doi:10.3390/molecules17089451

Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

1
Research and Development of Novel Drugs Unit, Center for Applied Pharmacobiology Research (CIFA), University of Navarre, Pamplona 31080, Spain
2
Malaria Group, University of Antioquia, Medellín, Colombia
3
UMR 152 PharmaDev (Pharmacologie et Pharmacochimie pour le Développement), Université de Toulouse, UPS, 118, rte de Narbonne, F-31062 Toulouse cedex 9, France
4
UMR 152 PharmaDev Institut de Recherche pour le Développement, Faculté des Sciences Pharmaceutiques, Université de Toulouse 3, 31062 Toulouse, France
*
Author to whom correspondence should be addressed.
Received: 28 June 2012 / Revised: 20 July 2012 / Accepted: 31 July 2012 / Published: 7 August 2012
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [205 KB, uploaded 18 June 2014]   |  

Abstract

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.
Keywords: quinoxaline; piperazine; Plasmodium; Leishmania; VERO quinoxaline; piperazine; Plasmodium; Leishmania; VERO
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Barea, C.; Pabón, A.; Galiano, S.; Pérez-Silanes, S.; Gonzalez, G.; Deyssard, C.; Monge, A.; Deharo, E.; Aldana, I. Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives. Molecules 2012, 17, 9451-9461.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top