Molecules 2012, 17(8), 9451-9461; doi:10.3390/molecules17089451
Article

Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

Received: 28 June 2012; in revised form: 20 July 2012 / Accepted: 31 July 2012 / Published: 7 August 2012
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties.
Keywords: quinoxaline; piperazine; Plasmodium; Leishmania; VERO
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MDPI and ACS Style

Barea, C.; Pabón, A.; Galiano, S.; Pérez-Silanes, S.; Gonzalez, G.; Deyssard, C.; Monge, A.; Deharo, E.; Aldana, I. Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives. Molecules 2012, 17, 9451-9461.

AMA Style

Barea C, Pabón A, Galiano S, Pérez-Silanes S, Gonzalez G, Deyssard C, Monge A, Deharo E, Aldana I. Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives. Molecules. 2012; 17(8):9451-9461.

Chicago/Turabian Style

Barea, Carlos; Pabón, Adriana; Galiano, Silvia; Pérez-Silanes, Silvia; Gonzalez, German; Deyssard, Chloe; Monge, Antonio; Deharo, Eric; Aldana, Ignacio. 2012. "Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives." Molecules 17, no. 8: 9451-9461.

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