Effect of Acute and Fractionated Irradiation on Hippocampal Neurogenesis
Abstract
:1. Introduction
2. Results and Discussions
3. Experimental
3.1. Chemicals and Mice
3.2. Ionizing Radiation in Mice
3.3. Immunohistochemistry
3.4. Statistics
4. Conclusions
Acknowledgments
References
- De Vos, K.J.; Grierson, A.J.; Ackerley, S.; Miller, C.C. Role of axonal transport in neurodegenerative diseases. Annu. Rev. Neurosci. 2008, 31, 151–173. [Google Scholar] [CrossRef]
- Estrada Sánchez, A.M.; Mejía-Toiber, J.; Massieu, L. Excitotoxic neuronal death and the pathogenesis of Huntington’s disease. Arch. Med. Res. 2008, 39, 265–276. [Google Scholar] [CrossRef]
- Thompson, L.M. Neurodegeneration: A question of balance. Nature 2008, 452, 707–708. [Google Scholar] [CrossRef]
- Wenk, G.L. Neuropathologic changes in Alzheimer’s disease. J. Clin. Psychiatry 2003, 9, 7–10. [Google Scholar]
- Eriksson, P.S.; Perfilieva, E.; Björk-Eriksson, T.; Alborn, A.M.; Nordborg, C.; Peterson, D.A.; Gage, F.H. Neurogenesis in the adult human hippocampus. Nat. Med. 1998, 4, 1313–1317. [Google Scholar]
- Goldman, S.A.; Nottebohm, F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proc. Natl. Acad. Sci. USA 1983, 80, 2390–2394. [Google Scholar]
- Shors, T.J.; Townsend, D.A.; Zhao, M.; Kozorovitskiy, Y.; Gould, E. Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 2002, 12, 578–584. [Google Scholar] [CrossRef]
- Couillard-Despres, S.; Winner, B.; Schaubeck, S.; Aigner, R.; Vroemen, M.; Weidner, N.; Bogdahn, U.; Winkler, J.; Kuhn, H.G.; Aigner, L. Doublecortin expression levels in adult brain reflect neurogenesis. Eur. J. Neurosci. 2005, 21, 1–14. [Google Scholar]
- Kuhn, H.G.; Dickinson-Anson, H.; Gage, F.H. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J. Neurosci. 1996, 16, 2027–2033. [Google Scholar]
- Parent, J.M.; Yu, T.W.; Leibowitz, R.T.; Geschwind, D.H.; Sloviter, R.S.; Lowenstein, D.H. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 1997, 17, 3727–3728. [Google Scholar]
- Scott, B.W.; Wang, S.; Burnham, W.M.; de Boni, U.; Wojtowicz, J.M. Kindling-induced neurogenesis in the dentate gyrus of the rat. Neurosci. Lett. 1998, 248, 73–76. [Google Scholar] [CrossRef]
- Young, D.; Lawlor, P.A.; Leone, P.; Dragunow, M.; During, M.J. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat. Med. 1999, 5, 448–453. [Google Scholar] [CrossRef]
- Chao, N.J. Accidental or intentional exposure to ionizing radiation: Biodosimetry and treatment options. Exp. Hematol. 2007, 35, 24–27. [Google Scholar] [CrossRef]
- Hall, E.J.; Giaccia, A.J. Radiobiology for the Radiologist, 6th ed; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2006. [Google Scholar]
- Baker, J.E.; Fish, B.L.; Su, J.; Haworth, S.T.; Strande, J.L.; Komorowski, R.A.; Migrino, R.Q.; Doppalapudi, A.; Harmann, L.; Li, X.A.; et al. 10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model. Int. J. Radiat. Biol. 2009, 85, 1089–1100. [Google Scholar] [CrossRef]
- Srinivasan, M.; Sudheer, A.R.; Pillai, K.R.; Kumar, P.R.; Sudhakaran, P.R.; Menon, V.P. Influence of ferulic acid on gamma-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes. Toxicology 2006, 228, 249–258. [Google Scholar] [CrossRef]
- Ben Abdallah, N.M.B.; Slomianka, L.; Lipp, H.P. Reversible effect of X-irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice. Hippocampus 2007, 17, 1230–1240. [Google Scholar] [CrossRef]
- Kim, J.S.; Lee, H.J.; Kim, J.C.; Kang, S.S.; Bae, C.S.; Shin, T.; Jin, J.K.; Kim, S.H.; Wang, H.; Moon, C. Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. J. Radiat. Res. 2008, 517–526. [Google Scholar]
- Kim, S.; Jang, B.S.; Jung, U.; Jo, S.K. Gamma-irradiation is more efficient at depleting hippocampal neurogenesis than D-galactose/NaNO2. Neurosci. Lett. 2011, 498, 47–51. [Google Scholar] [CrossRef]
- Manda, K.; Reiter, R.J. Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation. Prog. Neurobiol. 2010, 11, 60–68. [Google Scholar] [CrossRef]
- Manda, K.; Ueno, M.; Anzai, K. Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: Attenuation by melatonin pretreatment. J. Pineal Res. 2009, 46, 71–78. [Google Scholar] [CrossRef]
- Manda, K.; Ueno, M.; Anzai, K. Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: Ameliorative potential of the melatonin metabolite, AFMK. J. Pineal Res. 2008, 45, 430–438. [Google Scholar] [CrossRef]
- Acevedo, S.F.; McGinnis, G.; Raber, J. Effects of 137Cs γ Irradiation on Cognitive Performance and Measures of Anxiety of Apoe−/− and Wild-Type Female Mice. Radiat. Res. 2008, 170, 422–428. [Google Scholar] [CrossRef]
- Brown, J.P.; Couillard-Després, S.; Cooper-Kuhn, C.M.; Winkler, J.; Aigner, L.; Kuhn, H.G. Transient expression of doublecortin during adult neurogenesis. J. Comp. Neurol. 2003, 467, 1–10. [Google Scholar] [CrossRef]
- Yuan, H.; Gaber, M.W.; Wilson, C.M.; Kiani, M.F.; Merchant, T.E. Effects of fractionated radiation on the brain vasculature in a murine model: Blood brain barrier permeability, astrocyte proliferation, and ultrastructural changes. Int. J. Radiat. Oncol. Biol. Phys. 2006, 66, 860–866. [Google Scholar] [CrossRef]
- Park, H.R.; Jung, U.; Jo, S.K. Impairment of Natural Killer (NK) Cells is an Important Factor in a Weak Th1-like Response in Irradiated Mice. Radiat. Res. 2007, 168, 446–452. [Google Scholar] [CrossRef]
- Roh, C.; Choi, N.H.; Park, H.R.; Jung, U.; Jo, S.K. Effects of Orlistat on white adipose tissue (WAT) in the g-irradiated mouse model. Eur. J. Lipid Sci. Technol. 2010, 112, 1384–1388. [Google Scholar] [CrossRef]
- Sample Availability: Not available.
© 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Share and Cite
Park, M.-K.; Kim, S.; Jung, U.; Kim, I.; Kim, J.K.; Roh, C. Effect of Acute and Fractionated Irradiation on Hippocampal Neurogenesis. Molecules 2012, 17, 9462-9468. https://doi.org/10.3390/molecules17089462
Park M-K, Kim S, Jung U, Kim I, Kim JK, Roh C. Effect of Acute and Fractionated Irradiation on Hippocampal Neurogenesis. Molecules. 2012; 17(8):9462-9468. https://doi.org/10.3390/molecules17089462
Chicago/Turabian StylePark, Min-Kyoung, Seolhwa Kim, Uhee Jung, Insub Kim, Jin Kyu Kim, and Changhyun Roh. 2012. "Effect of Acute and Fractionated Irradiation on Hippocampal Neurogenesis" Molecules 17, no. 8: 9462-9468. https://doi.org/10.3390/molecules17089462