Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(8), 9443-9450; doi:10.3390/molecules17089443
Article

Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.

1
, 2,3
, 4
, 3,5
, 2
, 6
, 2,3,*  and 2,3,5,*
Received: 9 July 2012; in revised form: 1 August 2012 / Accepted: 2 August 2012 / Published: 7 August 2012
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [229 KB, uploaded 18 June 2014]   |   Browse Figures
Abstract: A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Cheng, C.-H.; Chung, H.-M.; Hwang, T.-L.; Lu, M.-C.; Wen, Z.-H.; Kuo, Y.-H.; Wang, W.-H.; Sung, P.-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules 2012, 17, 9443-9450.

AMA Style

Cheng C-H, Chung H-M, Hwang T-L, Lu M-C, Wen Z-H, Kuo Y-H, Wang W-H, Sung P-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules. 2012; 17(8):9443-9450.

Chicago/Turabian Style

Cheng, Ching-Hsiao; Chung, Hsu-Ming; Hwang, Tsong-Long; Lu, Mei-Chin; Wen, Zhi-Hong; Kuo, Yueh-Hsiung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.." Molecules 17, no. 8: 9443-9450.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert