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Molecules 2012, 17(8), 9443-9450; doi:10.3390/molecules17089443
Article

Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.

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2,3,*  and 2,3,5,*
1 Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan 2 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 3 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 9 July 2012 / Revised: 1 August 2012 / Accepted: 2 August 2012 / Published: 7 August 2012
(This article belongs to the Section Natural Products)
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Abstract

A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Cheng, C.-H.; Chung, H.-M.; Hwang, T.-L.; Lu, M.-C.; Wen, Z.-H.; Kuo, Y.-H.; Wang, W.-H.; Sung, P.-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules 2012, 17, 9443-9450.

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