Molecules 2012, 17(8), 9443-9450; doi:10.3390/molecules17089443
Article

Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.

1email, 2,3email, 4email, 3,5email, 2email, 6email, 2,3,* email and 2,3,5,* email
Received: 9 July 2012; in revised form: 1 August 2012 / Accepted: 2 August 2012 / Published: 7 August 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase
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MDPI and ACS Style

Cheng, C.-H.; Chung, H.-M.; Hwang, T.-L.; Lu, M.-C.; Wen, Z.-H.; Kuo, Y.-H.; Wang, W.-H.; Sung, P.-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules 2012, 17, 9443-9450.

AMA Style

Cheng C-H, Chung H-M, Hwang T-L, Lu M-C, Wen Z-H, Kuo Y-H, Wang W-H, Sung P-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules. 2012; 17(8):9443-9450.

Chicago/Turabian Style

Cheng, Ching-Hsiao; Chung, Hsu-Ming; Hwang, Tsong-Long; Lu, Mei-Chin; Wen, Zhi-Hong; Kuo, Yueh-Hsiung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.." Molecules 17, no. 8: 9443-9450.


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