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Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.
Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 9 July 2012; in revised form: 1 August 2012 / Accepted: 2 August 2012 / Published: 7 August 2012
Abstract: A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase
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Cheng, C.-H.; Chung, H.-M.; Hwang, T.-L.; Lu, M.-C.; Wen, Z.-H.; Kuo, Y.-H.; Wang, W.-H.; Sung, P.-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules 2012, 17, 9443-9450.
Cheng C-H, Chung H-M, Hwang T-L, Lu M-C, Wen Z-H, Kuo Y-H, Wang W-H, Sung P-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules. 2012; 17(8):9443-9450.
Cheng, Ching-Hsiao; Chung, Hsu-Ming; Hwang, Tsong-Long; Lu, Mei-Chin; Wen, Zhi-Hong; Kuo, Yueh-Hsiung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.." Molecules 17, no. 8: 9443-9450.