Molecules 2012, 17(8), 9443-9450; doi:10.3390/molecules17089443
Article

Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.

1 Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan 2 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 3 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 5 Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 6 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 9 July 2012; in revised form: 1 August 2012 / Accepted: 2 August 2012 / Published: 7 August 2012
(This article belongs to the Section Natural Products)
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Abstract: A new clerodane-type diterpenoid, echinoclerodane A (1), was isolated from a Formosan gorgonian coral Echinomuricea sp. The structure of 1 was elucidated by spectroscopic methods. Echinoclerodane A (1) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (1) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: Echinomuricea; clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase

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MDPI and ACS Style

Cheng, C.-H.; Chung, H.-M.; Hwang, T.-L.; Lu, M.-C.; Wen, Z.-H.; Kuo, Y.-H.; Wang, W.-H.; Sung, P.-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules 2012, 17, 9443-9450.

AMA Style

Cheng C-H, Chung H-M, Hwang T-L, Lu M-C, Wen Z-H, Kuo Y-H, Wang W-H, Sung P-J. Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.. Molecules. 2012; 17(8):9443-9450.

Chicago/Turabian Style

Cheng, Ching-Hsiao; Chung, Hsu-Ming; Hwang, Tsong-Long; Lu, Mei-Chin; Wen, Zhi-Hong; Kuo, Yueh-Hsiung; Wang, Wei-Hsien; Sung, Ping-Jyun. 2012. "Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.." Molecules 17, no. 8: 9443-9450.

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