Molecules 2012, 17(6), 6237-6248; doi:10.3390/molecules17066237
Article

Antiatherogenic Properties of Acetone Extract of Alpinia zerumbet Seeds

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Received: 2 May 2012; in revised form: 17 May 2012 / Accepted: 18 May 2012 / Published: 25 May 2012
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Oxidation of low-density lipoprotein (LDL) is the principal risk factor for the development of atherosclerosis. In this study, we used several methods to investigate the ability of the acetone extract from rhizomes, stems, leaves, flowers, pericarps and seeds of Alpinia zerumbet to inhibit atherosclerosis in vitro. The seed extract had the strongest activity against tyrosinase, pancreatic lipase (PL), 15-lipoxygenase (15-LO) and LDL oxidation activities (IC50 = 2.30 ± 0.02, 5.00 ± 0.07, 1.29 ± 0.07 and 15.40 ± 0.86 µg/mL, respectively), amongst all different parts. It also had similar effects to the positive controls. Most of the extracts showed partial agonistic properties towards estrogenic activity. Cholest-4-ene-3,6-dione, a steroid present only in the seed extract seems to be the compound responsible for these activities. The results showed that cholest-4-ene-3,6-dione had similar ability to curcumin and quercetin against PL and LDL oxidation (IC50 = 19.50 ± 1.17 and 16.12 ± 1.43 µg/mL, respectively). Furthermore, cholest-4-ene-3,6-dione (IC50 = 34.21 ± 1.31 µg/mL) had higher inhibition against 15-LO than quercetin (IC50 = 54.79 ± 1.12 µg/mL).
Keywords: Alpinia zerumbet; acetone extracts; atherosclerosis; LDL oxidation; cholest-4-ene-3,6-dione
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MDPI and ACS Style

Chompoo, J.; Upadhyay, A.; Gima, S.; Fukuta, M.; Tawata, S. Antiatherogenic Properties of Acetone Extract of Alpinia zerumbet Seeds. Molecules 2012, 17, 6237-6248.

AMA Style

Chompoo J, Upadhyay A, Gima S, Fukuta M, Tawata S. Antiatherogenic Properties of Acetone Extract of Alpinia zerumbet Seeds. Molecules. 2012; 17(6):6237-6248.

Chicago/Turabian Style

Chompoo, Jamnian; Upadhyay, Atul; Gima, Shinichi; Fukuta, Masakazu; Tawata, Shinkichi. 2012. "Antiatherogenic Properties of Acetone Extract of Alpinia zerumbet Seeds." Molecules 17, no. 6: 6237-6248.

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