Next Article in Journal
Synthesis of Chalcones with Anticancer Activities
Next Article in Special Issue
Catalytic Asymmetric Hydrogenation of 3-Substituted Benzisoxazoles
Previous Article in Journal
Chemical Constituents of the Ethyl Acetate Extract of Belamcanda chinensis (L.) DC Roots and Their Antitumor Activities
Previous Article in Special Issue
Chiral Aminophosphines as Catalysts for Enantioselective Double-Michael Indoline Syntheses
Molecules 2012, 17(5), 6170-6178; doi:10.3390/molecules17056170
Communication

Chiral Bis(Imidazolidine)Pyridine-Cu Complex-Catalyzed Enantioselective [3+2]-Cycloaddition of Azomethine Imines with Propiolates

*  and
Department of Chemistry, Graduate School of Science, Chiba University, 1-33, Yayoi, Inage, Chiba 263-8522, Japan
* Author to whom correspondence should be addressed.
Received: 27 April 2012 / Revised: 18 May 2012 / Accepted: 21 May 2012 / Published: 24 May 2012
(This article belongs to the Special Issue Asymmetric Catalysis)
Download PDF [284 KB, uploaded 18 June 2014]

Abstract

[3+2] Cycloaddition of azomethine imines with electron-deficient terminal alkynes was smoothly catalyzed by a chiral bis(imidazolidine)pyridine-CuOAc complex to give bicyclic pyrazolo[1,2-a]pyrazolone derivatives with up to 74% ee.
Keywords: pyrazolone; [3+2] cycloaddition; asymmetric synthesis; catalyst; chiral ligand pyrazolone; [3+2] cycloaddition; asymmetric synthesis; catalyst; chiral ligand
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Arai, T.; Ogino, Y. Chiral Bis(Imidazolidine)Pyridine-Cu Complex-Catalyzed Enantioselective [3+2]-Cycloaddition of Azomethine Imines with Propiolates. Molecules 2012, 17, 6170-6178.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert