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Molecules 2012, 17(5), 6071-6082; doi:10.3390/molecules17056071

Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated from Artocarpus obtusus F.M. Jarrett

1
Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
2
Department of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia
3
Faculty of Agriculture and Biotechnology, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, Malaysia
4
Department of Biology, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Received: 5 March 2012 / Revised: 17 April 2012 / Accepted: 20 April 2012 / Published: 21 May 2012
(This article belongs to the Section Medicinal Chemistry)
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Abstract

One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid.
Keywords: antimicrobial; antioxidant; antiproliferative; Artocarpus obtusus; pyranocycloartobiloxanthone A; tyrosinase inhibitory antimicrobial; antioxidant; antiproliferative; Artocarpus obtusus; pyranocycloartobiloxanthone A; tyrosinase inhibitory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hashim, N.M.; Rahmani, M.; Ee, G.C.L.; Sukari, M.A.; Yahayu, M.; Amin, M.A.M.; Ali, A.M.; Go, R. Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated from Artocarpus obtusus F.M. Jarrett. Molecules 2012, 17, 6071-6082.

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